Epigenetic and microenvironmental regulation of dormant disseminated cancer

Project: Research project

Project Details

Description

NARRATIVE: Metastases can arise from dormant disseminated tumor cells (DTCs) years after primary tumor resection. We will study unexplored areas of DTC biology including how target organ niche cues (TGFβ2, IL6), epigenetic regulators (macroH2A and ARID1A), and specific chromatin states, promote dormancy of DTCs.
StatusFinished
Effective start/end date6/7/175/31/22

Funding

  • National Cancer Institute: $499,826.00
  • National Cancer Institute: $445,511.00
  • National Cancer Institute: $428,136.00
  • National Cancer Institute: $428,136.00
  • National Cancer Institute: $428,136.00

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