Dissection of molecular events driving alphavirus entry and assembly

Project: Research project

Project Details

Description

Alphaviruses include important human pathogens that cause serious diseases and are potential biodefense threats, and for which there are no antiviral therapies. This project will study the molecular mechanisms by which alphaviruses specifically recruit the viral RNA genome and assemble it into the viral core, and interact with a receptor to enter and infect the host cell. We will also explore a novel inhibitor of core formation, which acts as an experimental tool and a potential future approach to antiviral strategies.
StatusActive
Effective start/end date8/1/0711/30/22

Funding

  • National Institute of Allergy and Infectious Diseases: $633,513.00
  • National Institute of Allergy and Infectious Diseases: $653,224.00
  • National Institute of Allergy and Infectious Diseases: $505,341.00
  • National Institute of Allergy and Infectious Diseases: $525,632.00
  • National Institute of Allergy and Infectious Diseases: $599,881.00
  • National Institute of Allergy and Infectious Diseases: $540,778.00
  • National Institute of Allergy and Infectious Diseases: $76,877.00
  • National Institute of Allergy and Infectious Diseases: $272,177.00
  • National Institute of Allergy and Infectious Diseases: $633,513.00
  • National Institute of Allergy and Infectious Diseases: $653,224.00
  • National Institute of Allergy and Infectious Diseases: $536,410.00
  • National Institute of Allergy and Infectious Diseases: $653,224.00
  • National Institute of Allergy and Infectious Diseases: $535,843.00
  • National Institute of Allergy and Infectious Diseases: $60,584.00
  • National Institute of Allergy and Infectious Diseases: $633,513.00
  • National Institute of Allergy and Infectious Diseases: $381,047.00
  • National Institute of Allergy and Infectious Diseases: $510,692.00

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