Beta Cell Intracellular Calcium and Diabetes

Project: Research project

Project Details

Description

The prevalence of diabetes is dramatically increasing, affecting more than 7.5 billion people worldwide, with a significant economic burden, quantified in >$327 billion/year only in the United States, where 1 out of 3 adults has prediabetes. This is the first investigation into the mechanistic role of a major intracellular calcium release channel within the pancreatic beta cell in the pathogenesis of diabetes, using a novel and specific murine model. Our studies, relevant to public health and to the NIH mission to discover basic mechanisms underlying human disease, suggest an unprecedented role for this channel in the pathophysiology of diabetes via a pathway that involves the regulation of mitochondrial quality control.
StatusActive
Effective start/end date1/1/2011/30/22

Funding

  • National Institute of Diabetes and Digestive and Kidney Diseases: $418,750.00
  • National Institute of Diabetes and Digestive and Kidney Diseases: $376,875.00
  • National Institute of Diabetes and Digestive and Kidney Diseases: $376,875.00

Fingerprint

Explore the research topics touched on by this project. These labels are generated based on the underlying awards/grants. Together they form a unique fingerprint.