AGING AND PERIPHERAL AND HEPATIC GLUCOSE METABOLISM

Project: Research project

Project Details

Description

In this proposal We hypothesize that derangement's in carbohydrate
metabolism of aging is associated with parallel changes in body
composition. We plan to demonstrate these changes during the life
span of rats, focusing mainly on muscle and hepatic glucose metabolism
and intracellular pathways. We also hypothesize that caloric
restriction may reverse many of the derangement's in glucose
metabolism of aging rats. Our Specific Aims are to study in aging
rats: 1) The effects of body composition and plasma FFA concentration
on insulin- and glucose-mediated glucose disposal, glycolysis, and
glycogen synthesis. 2) The effects of body composition and plasma FFA
concentration on in vivo hepatic glucose fluxes, glycogenolysis,
gluconeogenesis. 3) The correlation between the specific alterations
in in vivo hepatic and skeletal muscle glucose fluxes and the in vitro
kinetics of the rate-determining enzymes of these metabolic pathways,
such as glycogen synthase, glucokinase and glucose-6-phosphatase. 4)
The impact of early intervention by caloric restriction on body
composition and peripheral and hepatic glucose fluxes. Studies will
be conducted in 2 rat models: Fischer 344 and Sprauge-Dawley, in 4
different age groups. The significance of this proposal is two fold.
First it will quantify the role of increased fat mass on glucose
metabolism in aging. Second, if not all impairment is fat mass
related, it may point to the mechanisms that are true senescence.
StatusFinished
Effective start/end date9/1/948/31/95

Funding

  • National Institute on Aging

ASJC

  • Geriatrics and Gerontology
  • Physiology (medical)
  • Endocrinology
  • Nutrition and Dietetics
  • Endocrinology, Diabetes and Metabolism

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