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Acute Myeloid Leukemia Medicine & Life Sciences
Myelodysplastic Syndromes Medicine & Life Sciences
Hematopoietic Stem Cells Medicine & Life Sciences
Stem Cells Medicine & Life Sciences
Leukemia Medicine & Life Sciences
Stem cells Chemical Compounds
Epigenomics Medicine & Life Sciences
Neoplasms Medicine & Life Sciences

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Grants 2008 2022

Stem Cells
Small Interfering RNA
Leukemia
Recurrence
Critical Pathways
Homeobox Genes
Acute Myeloid Leukemia
Transcription Factors
Leukemia
Critical Pathways

Transcriptional regulation of leukemic stem cells in acute myeloid leukemia

Steidl, U. G.

National Institutes of Health

9/1/084/30/12

Project: Research projectResearch Transition Award, Career Transition Award

Acute Myeloid Leukemia
Stem Cells
Leukemia
Transcription Factors
Maintenance

Publications 1998 2018

Dual inhibition of MDMX and MDM2 as a therapeutic strategy in leukemia

Carvajal, L. A. , Ben Neriah, D. , Senecal, A. , Benard, L. , Thiruthuvanathan, V. , Yatsenko, T. , Narayanagari, S. R. , Wheat, J. C. , Todorova, T. I. , Mitchell, K. , Kenworthy, C. , Guerlavais, V. , Annis, D. A. , Bartholdy, B. , Will, B. , Anampa, J. D. , Mantzaris, I. , Aivado, M. , Singer, R. H. , Coleman, R. A. & 2 others Verma, A. & Steidl, U. Apr 11 2018 In : Science Translational Medicine. 10, 436, aao3003

Research output: Contribution to journalArticle

Leukemia
Acute Myeloid Leukemia
Neoplasms
Therapeutics
Cell Cycle Checkpoints

Dynamic Regulation of Long-Chain Fatty Acid Oxidation by a Noncanonical Interaction between the MCL-1 BH3 Helix and VLCAD

Escudero, S., Zaganjor, E., Lee, S., Mill, C. P., Morgan, A. M., Crawford, E. B., Chen, J., Wales, T. E., Mourtada, R., Luccarelli, J., Bird, G. H., Steidl, U., Engen, J. R., Haigis, M. C., Opferman, J. T. & Walensky, L. D. Mar 1 2018 In : Molecular Cell. 69, 5, p. 802-819.e1

Research output: Contribution to journalArticle

Long-Chain Acyl-CoA Dehydrogenase
Mitochondria
Fatty Acids
Apoptosis
Lipid Metabolism

IL1RAP potentiates multiple oncogenic signaling pathways in AML

Mitchell, K., Barreyro, L., Todorova, T. I., Taylor, S. J., Antony-Debré, I., Narayanagari, S. R., Carvajal, L. A., Leite, J., Piperdi, Z., Pendurti, G., Mantzaris, I., Paietta, E., Verma, A., Gritsman, K. & Steidl, U. Jun 1 2018 In : Journal of Experimental Medicine. 215, 6, p. 1709-1727 19 p.

Research output: Contribution to journalArticle

Interleukin-1 Receptor Accessory Protein
Acute Myeloid Leukemia
Interleukin-1 Receptors
Receptor Protein-Tyrosine Kinases
Protein Transport
1 Citations

LSD1 inhibition exerts its antileukemic effect by recommissioning PU.1- and C/EBPa-dependent enhancers in AML

Cusan, M., Cai, S. F., Mohammad, H., Krivtsov, A., Chramiec, A., Loizou, E., Witkin, M. D., Smitheman, K. N., Tenen, D. G., Ye, M., Will, B., Steidl, U., Kruger, R. G., Levine, R. L., Rienhoff, H. Y., Koche, R. P. & Armstrong, S. A. Apr 12 2018 In : Blood. 131, 15, p. 1730-1742 13 p.

Research output: Contribution to journalArticle

Rotary engines
Efflorescence
Acute Myeloid Leukemia
Lysine
Leukemia
1 Citations

Macrocytosis and dysplastic anemia is associated with the cyclin-dependent kinase 4/6 inhibitor palbociclib in metastatic breast cancer

Anampa, J., Haque, T., Murakhovskaya, I., Wang, Y., Bachiashvili, K., Papazoglu, C., Pradhan, K., Steidl, U. G., Sparano, J. A. & Verma, A. Feb 28 2018 In : Haematologica. 103, 3, p. e98-e102

Research output: Contribution to journalLetter

Cyclin-Dependent Kinase 6
Cyclin-Dependent Kinase 4
Anemia
Breast Neoplasms
palbociclib