• 12110 Citations
  • 53 h-Index
1987 …2020

Research output per year

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Publications

2020

Leptin-mediated differential regulation of microsomal triglyceride transfer protein in the intestine and liver affects plasma lipids

Iqbal, J., Mascareno, E., Chua, S. & Mahmood Hussain, M., Mar 27 2020, In : Journal of Biological Chemistry. 295, 13, p. 4101-4113 13 p.

Research output: Contribution to journalArticle

1 Scopus citations

Neuronal Cell Cycle Events Link Caloric Intake to Obesity

Iqbal, N., Zhu, LI. I. & Chua, S. C., Jan 2020, In : Trends in Endocrinology and Metabolism. 31, 1, p. 46-52 7 p.

Research output: Contribution to journalReview article

1 Scopus citations
2018

Activation of temperature-sensitive TRPV1-like receptors in ARC POMC neurons reduces food intake

Jeong, J. H., Lee, D. K., Liu, S. M., Chua, S. C., Schwartz, G. J. & Jo, Y. H., Apr 24 2018, In : PLoS biology. 16, 4, e2004399.

Research output: Contribution to journalArticle

17 Scopus citations

A gut–brain axis regulating glucose metabolism mediated by bile acids and competitive fibroblast growth factor actions at the hypothalamus

Liu, S., Marcelin, G., Blouet, C., Jeong, J. H., Jo, Y. H., Schwartz, G. J. & Chua, S., Feb 2018, In : Molecular Metabolism. 8, p. 37-50 14 p.

Research output: Contribution to journalArticle

16 Scopus citations

Cutting edge: Elevated leptin during diet-induced obesity reduces the efficacy of tumor immunotherapy

Murphy, K. A., James, B. R., Sjaastad, F. V., Kucaba, T. A., Kim, H., Brincks, E. L., Chua, S. C., Wilber, A. & Griffith, T. S., Oct 1 2018, In : Journal of Immunology. 201, 7, p. 1837-1841 5 p.

Research output: Contribution to journalArticle

7 Scopus citations

Cyclin-dependent kinase 4 is a preclinical target for diet-induced obesity

Iqbal, N. J., Lu, Z., Liu, S. M., Schwartz, G. J., Chua, S. & Zhu, L., Sep 6 2018, In : JCI Insight. 3, 17

Research output: Contribution to journalArticle

4 Scopus citations

Leptin function and regulation

Zhang, Y. & Chua, Jr., S. C., Jan 1 2018, In : Comprehensive Physiology. 8, 1, p. 351-369 19 p.

Research output: Contribution to journalArticle

15 Scopus citations
2017

ARC is essential for maintaining pancreatic islet structure and β-cell viability during type 2 diabetes

McKimpson, W. M., Zheng, M., Chua, Jr., S. C., Pessin, J. E. & Kitsis, R. N., Dec 1 2017, In : Scientific Reports. 7, 1, 7019.

Research output: Contribution to journalArticle

1 Scopus citations

mTORC1 in AGRP neurons integrates exteroceptive and interoceptive food-related cues in the modulation of adaptive energy expenditure in mice

Burke, L. K., Darwish, T., Cavanaugh, A. R., Virtue, S., Roth, E., Morro, J., Liu, S. M., Xia, J., Dalley, J. W., Burling, K., Chua, S., Vidal-Puig, T., Schwartz, G. J. & Blouet, C., May 23 2017, In : eLife. 6, e22848.

Research output: Contribution to journalArticle

17 Scopus citations
2016

FGF 19 and Bile Acids Increase Following Roux-en-Y Gastric Bypass but Not After Medical Management in Patients with Type 2 Diabetes

Sachdev, S., Wang, Q., Billington, C., Connett, J., Ahmed, L., Inabnet, W., Chua, S., Ikramuddin, S. & Korner, J., May 1 2016, In : Obesity Surgery. 26, 5, p. 957-965 9 p.

Research output: Contribution to journalArticle

55 Scopus citations

Single-cell gene expression analysis of cholinergic neurons in the arcuate nucleus of the hypothalamus

Jeong, J. H., JaeWoo, Y., Chua, S. & Jo, Y. H., Sep 2016, In : PloS one. 11, 9, e0162839.

Research output: Contribution to journalArticle

15 Scopus citations
2015

Cholinergic neurons in the dorsomedial hypothalamus regulate mouse brown adipose tissue metabolism

Jeong, J. H., Lee, D. K., Blouet, C., Ruiz, H. H., Buettner, C., Chua, S., Schwartz, G. J. & Jo, Y. H., Jun 1 2015, In : Molecular Metabolism. 4, 6, p. 483-492 10 p.

Research output: Contribution to journalArticle

23 Scopus citations

Interplay between glucose and leptin signalling determines the strength of GABAergic synapses at POMC neurons

Lee, D. K., Jeong, J. H., Chun, S. K., Chua, S. & Jo, Y. H., Mar 2015, In : Nature communications. 6, 6618.

Research output: Contribution to journalArticle

17 Scopus citations

Leptin potentiates astrogenesis in the developing hypothalamus

Rottkamp, D. M., Rudenko, I. A., Maier, M. T., Roshanbin, S., Yulyaningsih, E., Perez, L., Valdearcos, M., Chua, S., Koliwad, S. K. & Xu, A. W., Nov 2015, In : Molecular Metabolism. 4, 11, p. 881-889 9 p.

Research output: Contribution to journalArticle

23 Scopus citations

Loss of the RNA polymerase III repressor MAF1 confers obesity resistance

Bonhoure, N., Byrnes, A., Moir, R. D., Hodroj, W., Preitner, F., Praz, V., Marcelin, G., Chua, S. C., Martinez-Lopez, N., Singh, R., Moullan, N., Auwerx, J., Willemin, G., Shah, H., Hartil, K., Vaitheesvaran, B., Kurland, I., Hernandez, N. & Willis, I. M., May 1 2015, In : Genes and Development. 29, 9, p. 934-947 14 p.

Research output: Contribution to journalArticle

Open Access
47 Scopus citations
2014

Central action of FGF19 reduces hypothalamic AGRP/NPY neuron activity and improves glucose metabolism

Marcelin, G., Jo, Y. H., Li, X., Schwartz, G. J., Zhang, Y., Dun, N. J., Lyu, R. M., Blouet, C., Chang, J. K. & Chua, S., Feb 2014, In : Molecular Metabolism. 3, 1, p. 19-28 10 p.

Research output: Contribution to journalArticle

68 Scopus citations

Intestinal deletion of leptin signaling alters activity of nutrient transporters and delayed the onset of obesity in mice

Tavernier, A., Cavin, J. B., Le Gall, M., Ducroc, R., Denis, R. G. P., Cluzeaud, F., Guilmeau, S., Sakar, Y., Barbot, L., Kapel, N., Le Beyec, J., Joly, F., Chua, S., Luquet, S. & Bado, A., Sep 1 2014, In : FASEB Journal. 28, 9, p. 4100-4110 11 p.

Research output: Contribution to journalArticle

21 Scopus citations

Role of melanocortin signaling in neuroendocrine and metabolic actions of leptin in male rats with uncontrolled diabetes

Meek, T. H., Matsen, M. E., Damian, V., Cubelo, A., Chua, S. C. & Morton, G. J., Nov 1 2014, In : Endocrinology. 155, 11, p. 4157-4167 11 p.

Research output: Contribution to journalArticle

15 Scopus citations

The antidepressant trans-2-phenylcyclopropylamine protects mice from high-fat-diet-induced obesity

Shemesh, A., Abdulla, A., Yang, F., Chua, S. C., Pessin, J. E. & Zong, H., Feb 21 2014, In : PloS one. 9, 2, e89199.

Research output: Contribution to journalArticle

1 Scopus citations
2013

Agouti-related peptide plays a critical role in leptin's effects on female puberty and reproduction

Sheffer-Babila, S., Sun, Y., Israel, D. D., Liu, S. M., Neal-Perry, G. & Chua, S. C., Dec 15 2013, In : American Journal of Physiology - Endocrinology and Metabolism. 305, 12, p. E1512-E1520

Research output: Contribution to journalArticle

43 Scopus citations

Coordinated regulation of hepatic energy stores by Leptin and hypothalamic agouti-related protein

Warne, J. P., Varonin, J. M., Nielsen, S. S., Olofsson, L. E., Kaelin, C. B., Streamson, C., Barsh, G. S., Koliwad, S. K. & Xu, A. W., Jul 26 2013, In : Journal of Neuroscience. 33, 29, p. 11972-11985 14 p.

Research output: Contribution to journalArticle

7 Scopus citations

Identification of a loss-of-function mutation in ube2l6 associated with obesity resistance

Marcelin, G., Liu, S. M., Schwartz, G. J. & Chua, S. C., Aug 1 2013, In : Diabetes. 62, 8, p. 2784-2795 12 p.

Research output: Contribution to journalArticle

10 Scopus citations

Lentivirus-Mediated α-Melanocyte-Stimulating Hormone Overexpression in the Hypothalamus Decreases Diet Induced Obesity in Mice

Eerola, K., Nordlund, W., Virtanen, S., Dickens, A. M., Mattila, M., Ruohonen, S. T., Chua, S. C., Wardlaw, S. L., Savontaus, M. & Savontaus, E., Dec 1 2013, In : Journal of Neuroendocrinology. 25, 12, p. 1298-1307 10 p.

Research output: Contribution to journalArticle

11 Scopus citations

Leptin suppresses anti-Mullerian hormone gene expression through the JAK2/STAT3 pathway in luteinized granulosa cells of women undergoing IVF

Merhi, Z., Buyuk, E., Berger, D. S., Zapantis, A., Israel, D. D., Chua, S. & Jindal, S., Jun 2013, In : Human Reproduction. 28, 6, p. 1661-1669 9 p.

Research output: Contribution to journalArticle

49 Scopus citations

PRb is an obesity suppressor in hypothalamus and high-fat diet inhibits pRb in this location

Lu, Z., Marcelin, G., Bauzon, F., Wang, H., Fu, H., Dun, S. L., Zhao, H., Li, X., Jo, Y. H., Wardlaw, S., Dun, N., Chua, S. & Zhu, L., Mar 20 2013, In : EMBO Journal. 32, 6, p. 844-857 14 p.

Research output: Contribution to journalArticle

11 Scopus citations

Selective deletion of leptin receptors in adult hippocampus induces depression-related behaviours

Guo, M., Huang, T. Y., Garza, J. C., Chua, S. C. & Lu, X. Y., May 2013, In : International Journal of Neuropsychopharmacology. 16, 4, p. 857-867 11 p.

Research output: Contribution to journalArticle

49 Scopus citations

The apoptosis inhibitor ARC alleviates the ER stress response to promote β-cell survival

McKimpson, W. M., Weinberger, J., Czerski, L., Zheng, M., Crow, M. T., Pessin, J. E., Chua, S. C. & Kitsis, R. N., Jan 1 2013, In : Diabetes. 62, 1, p. 183-193 11 p.

Research output: Contribution to journalArticle

16 Scopus citations

The brain-liver connection between BDNF and glucose control

Jo, Y. H. & Chua, S. C., May 1 2013, In : Diabetes. 62, 5, p. 1367-1368 2 p.

Research output: Contribution to journalComment/debate

3 Scopus citations
2012

Ablation of leptin signaling to somatotropes: Changes in metabolic factors that cause obesity

Akhter, N., Odle, A. K., Allensworth-James, M. L., Haney, A. C., Syed, M. M., Cozart, M. A., Chua, S., Kineman, R. & Childs, G. V., Oct 1 2012, In : Endocrinology. 153, 10, p. 4705-4715 11 p.

Research output: Contribution to journalArticle

13 Scopus citations

Adipocyte Dysfunction in a Mouse Model of Polycystic Ovary Syndrome (PCOS): Evidence of Adipocyte Hypertrophy and Tissue-Specific Inflammation

Marino, J. S., Iler, J., Dowling, A. R., Chua, S., Bruning, J. C., Coppari, R. & Hill, J. W., Oct 31 2012, In : PloS one. 7, 10, e48643.

Research output: Contribution to journalArticle

17 Scopus citations

Effects of leptin and melanocortin signaling interactions on pubertal development and reproduction

Israel, D. D., Sheffer-Babila, S., De Luca, C., Jo, Y. H., Liu, S. M., Xia, Q., Spergel, D. J., Dun, S. L., Dun, N. J. & Chua, S. C., May 2012, In : Endocrinology. 153, 5, p. 2408-2419 12 p.

Research output: Contribution to journalArticle

67 Scopus citations

Endothelial leptin receptor mutation provides partial resistance to diet-induced obesity

Pan, W., Hsuchou, H., Cornelissen-Guillaume, G. G., Jayaram, B., Wang, Y., Tu, H., Halberg, F., Wu, X., Chua, S. C. & Kastin, A. J., Apr 15 2012, In : Journal of applied physiology. 112, 8, p. 1410-1418 9 p.

Research output: Contribution to journalArticle

13 Scopus citations

Forebrain glutamatergic neurons mediate leptin action on depression-like behaviors and synaptic depression

Guo, M., Lu, Y., Garza, J. C., Li, Y., Chua, S. C., Zhang, W., Lu, B. & Lu, X. Y., 2012, In : Translational psychiatry. 2, e83.

Research output: Contribution to journalArticle

50 Scopus citations

Genetic control of ATGL-mediated lipolysis modulates adipose triglyceride stores in leptin-deficient mice

Marcelin, G., Liu, S. M., Li, X., Schwartz, G. J. & Chua, S., May 1 2012, In : Journal of Lipid Research. 53, 5, p. 964-972 9 p.

Research output: Contribution to journalArticle

11 Scopus citations

Regulation of prolactin in mice with altered hypothalamic melanocortin activity

Dutia, R., Kim, A. J., Mosharov, E., Savontaus, E., Chua, S. C. & Wardlaw, S. L., Sep 1 2012, In : Peptides. 37, 1, p. 6-12 7 p.

Research output: Contribution to journalArticle

2 Scopus citations

Response of adipose tissue to early infection with trypanosoma cruzi (Brazil Strain)

Nagajyothi, F., Desruisseaux, M. S., MacHado, F. S., Upadhya, R., Zhao, D., Schwartz, G. J., Teixeira, M. M., Albanese, C., Lisanti, M. P., Chua, S. C., Weiss, L. M., Scherer, P. E. & Tanowitz, H. B., Mar 1 2012, In : Journal of Infectious Diseases. 205, 5, p. 830-840 11 p.

Research output: Contribution to journalArticle

41 Scopus citations

TXNIP in Agrp neurons regulates adiposity, energy expenditure, and central leptin sensitivity

Blouet, C., Liu, S. M., Jo, Y. H., Chua, S. & Schwartz, G. J., Jul 18 2012, In : Journal of Neuroscience. 32, 29, p. 9870-9877 8 p.

Research output: Contribution to journalArticle

25 Scopus citations
2011

Adipose-selective overexpression of ABHD5/CGI-58 does not increase lipolysis or protect against diet-induced obesity

Caviglia, J. M., Betters, J. L., Dapito, D. H., Lord, C. C., Sullivan, S., Chua, S., Yin, T., Sekowski, A., Mu, H., Shapiro, L., Brown, J. M. & Brasaemle, D. L., Nov 1 2011, In : Journal of Lipid Research. 52, 11, p. 2032-2042 11 p.

Research output: Contribution to journalArticle

14 Scopus citations

Adipose tissue, diabetes and chagas disease

Tanowitz, H. B., Jelicks, L. A., Machado, F. S., Esper, L., Qi, X., Desruisseaux, M. S., Chua, S. C., Scherer, P. E. & Nagajyothi, F., 2011, Advances in Parasitology. Academic Press, p. 235-250 16 p. (Advances in Parasitology; vol. 76).

Research output: Chapter in Book/Report/Conference proceedingChapter

17 Scopus citations

A mutation in the leptin receptor is associated with Entamoeba histolytica infection in children

Duggal, P., Guo, X., Haque, R., Peterson, K. M., Ricklefs, S., Mondal, D., Alam, F., Noor, Z., Verkerke, H. P., Marie, C., Leduc, C. A., Chua, S. C., Myers, M. G., Leibel, R. L., Houpt, E., Gilchrist, C. A., Sher, A., Porcella, S. F. & Petri, W. A., Mar 1 2011, In : Journal of Clinical Investigation. 121, 3, p. 1191-1198 8 p.

Research output: Contribution to journalArticle

98 Scopus citations

Effects of cell-type specific leptin receptor mutation on leptin transport across the BBB

Hsuchou, H., Kastin, A. J., Tu, H., Markadakis, E. N., Stone, K. P., Wang, Y., Heymsfield, S. B., Chua, S. S., Obici, S., Magrisso, I. J. & Pan, W., Jul 2011, In : Peptides. 32, 7, p. 1392-1399 8 p.

Research output: Contribution to journalArticle

15 Scopus citations

Leptin Action on GABAergic Neurons Prevents Obesity and Reduces Inhibitory Tone to POMC Neurons

Vong, L., Ye, C., Yang, Z., Choi, B., Chua, S. & Lowell, B. B., Jul 14 2011, In : Neuron. 71, 1, p. 142-154 13 p.

Research output: Contribution to journalArticle

512 Scopus citations

Leptin's effect on puberty in mice is relayed by the ventral premammillary nucleus and does not require signaling in Kiss1 neurons

Donato, J., Cravo, R. M., Frazão, R., Gautron, L., Scott, M. M., Lachey, J., Castro, I. A., Margatho, L. O., Lee, S., Lee, C., Richardson, J. A., Friedman, J., Chua, S., Coppari, R., Zigman, J. M., Elmquist, J. K. & Elias, C. F., Jan 4 2011, In : Journal of Clinical Investigation. 121, 1, p. 355-368 14 p.

Research output: Contribution to journalArticle

206 Scopus citations

Leptin signaling in intestinal epithelium mediates resistance to enteric infection by Entamoeba histolytica

Guo, X., Roberts, M. R., Becker, S. M., Podd, B., Zhang, Y., Chua, S. C., Myers, M. G., Duggal, P., Houpt, E. R. & Petri, W. A., May 2011, In : Mucosal Immunology. 4, 3, p. 294-303 10 p.

Research output: Contribution to journalArticle

73 Scopus citations

Neuropeptide Y and agouti-related peptide mediate complementary functions of hyperphagia and reduced energy expenditure in leptin receptor deficiency

Luo, N., Marcelin, G., Liu, S. M., Schwartz, G. & Chua, S., Mar 1 2011, In : Endocrinology. 152, 3, p. 883-889 7 p.

Research output: Contribution to journalArticle

14 Scopus citations

The somatotrope as a metabolic sensor: Deletion of leptin receptors causes obesity

Childs, G. V., Akhter, N., Haney, A., Syed, M., Odle, A., Cozart, M., Brodrick, Z., Gaddy, D., Suva, L. J., Akel, N., Crane, C., Beneš, H., Charlesworth, A., Luque, R., Chua, S. & Kineman, R. D., Jan 2011, In : Endocrinology. 152, 1, p. 69-81 13 p.

Research output: Contribution to journalArticle

33 Scopus citations
2010

An intrinsic gut leptin-melanocortin pathway modulates intestinal microsomal triglyceride transfer protein and lipid absorption

Iqbal, J., Li, X., Chang, B. H. J., Chan, L., Schwartz, G. J., Chua, S. C. & Hussain, M. M., Jul 1 2010, In : Journal of Lipid Research. 51, 7, p. 1929-1942 14 p.

Research output: Contribution to journalArticle

48 Scopus citations

A susceptibility gene for kidney disease in an obese mouse model of type II diabetes maps to chromosome 8

Chua, S., Li, Y., Liu, S. M., Liu, R., Chan, K. T., Martino, J., Zheng, Z., Susztak, K., D'Agati, V. D. & Gharavi, A. G., Sep 2010, In : Kidney international. 78, 5, p. 453-462 10 p.

Research output: Contribution to journalArticle

15 Scopus citations

CNS leptin action modulates immune response and survival in sepsis

Tschöp, J., Nogueiras, R., Haas-Lockie, S., Kasten, K. R., Castañeda, T. R., Huber, N., Guanciale, K., Perez-Tilve, D., Habegger, K., Ottaway, N., Woods, S. C., Oldfield, B., Clarke, I., Streamson, C., Farooqi, I. S., O'Rahilly, S., Caldwell, C. C. & Tschöp, M. H., Apr 28 2010, In : Journal of Neuroscience. 30, 17, p. 6036-6047 12 p.

Research output: Contribution to journalArticle

59 Scopus citations

Contributions of adipocyte lipid metabolism to body fat content and implications for the treatment of obesity

Marcelin, G. & Chua, S., Oct 1 2010, In : Current Opinion in Pharmacology. 10, 5, p. 588-593 6 p.

Research output: Contribution to journalReview article

27 Scopus citations