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Steven C. Almo, Ph.D.

  • 14862 Citations
  • 66 h-Index
1977 …2024
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Catalytic Domain Medicine & Life Sciences
Enzymes Medicine & Life Sciences
Actins Medicine & Life Sciences
Proteins Medicine & Life Sciences
Ligands Medicine & Life Sciences
Profilins Medicine & Life Sciences
Substrates Chemical Compounds
Crystal structure Chemical Compounds

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Grants 1977 2024

Novel Biologics Designed to Mobilize HIV-specific CTL for Sustained HIV Remission

Goldstein, H. & Almo, S. C.

National Institutes of Health

4/5/19 → 3/31/24

Project: Research project

Biological Products
HIV
T-Lymphocytes
Cytokines
Viremia

An immunotherapeutic strategy for the induction and stabilization of remission in type 1 diabetes

Almo, S. C. & DiLorenzo, T. P.

National Institutes of Health

9/15/18 → 7/31/21

Project: Research project

Remission Induction
Type 1 Diabetes Mellitus
T-Lymphocytes
Antigens
Immunological Synapses

Structural, functional, and mechanistic anlaysis of autoreactive CD8 T cells

Almo, S. C. & DiLorenzo, T. P.

National Institutes of Health

2/8/18 → 1/31/23

Project: Research project

T-Lymphocytes
Alleles
T-Cell Antigen Receptor
Type 1 Diabetes Mellitus
Peptides

Structural basis of allostery and mechanical properties of F-actin

Almo, S. C.

National Institutes of Health

8/1/16 → 7/31/20

Project: Research project

Actins
Mechanical properties
Microfilament Proteins
Protein Subunits
Electron microscopy

Novel Strategies for the Discovery of Microbial Metabolic Pathways

Almo, S. C.

National Institutes of Health

6/15/16 → 4/30/21

Project: Research project

Carrier Proteins
Ligands
Proteins
Metabolic Networks and Pathways
Microbiota

Publications 1988 2019

An essential bifunctional enzyme in Mycobacterium tuberculosis for itaconate dissimilation and leucine catabolism

Wang, H., Fedorov, A. A., Fedorov, E. V., Hunt, D. M., Rodgers, A., Douglas, H. L., Garza-Garcia, A., Bonanno, J. B., Almo, S. C. & de Carvalho, L. P. S., Aug 6 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 32, p. 15907-15913 7 p.

Research output: Contribution to journal › Article

Open Access
Mycobacterium tuberculosis
Leucine
Enzymes
Mycobacterium Infections
Lyases

Computational Redesign of PD-1 Interface for PD-L1 Ligand Selectivity

Shrestha, R., Garrett, S. C., Almo, S. C. & Fiser, A., May 7 2019, In : Structure. 27, 5, p. 829-836.e3

Research output: Contribution to journal › Article

Cell Death
Ligands
Programmed Cell Death 1 Receptor
T-Lymphocytes
Human Engineering

Discovery of novel bacterial queuine salvage enzymes and pathways in human pathogens

Yuan, Y., Zallot, R., Grove, T. L., Payan, D. J., Martin-Verstraete, I., Šepić, S., Balamkundu, S., Neelakandan, R., Gadi, V. K., Liu, C. F., Swairjo, M. A., Dedon, P. C., Almo, S. C., Gerlt, J. A. & de Crécy-Lagard, V., Sep 17 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 38, p. 19126-19135 10 p.

Research output: Contribution to journal › Article

Open Access
Bacteria
queuine tRNA-ribosyltransferase
Enzymes
Eukaryota
Nucleoside Q
1 Citation (Scopus)

Genetically modified hematopoietic stem/progenitor cells that produce IL-10–secreting regulatory T cells

Ng, S. L., Leno-Duran, E., Samanta, D., Almo, S. C. & Strominger, J. L., Feb 12 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 7, p. 2634-2639 6 p.

Research output: Contribution to journal › Article

Regulatory T-Lymphocytes
Hematopoietic Stem Cells
Autoimmune Experimental Encephalomyelitis
T-Cell Antigen Receptor
Interleukin-10
4 Citations (Scopus)

GPRC5D is a target for the immunotherapy of multiple myeloma with rationally designed CAR T cells

Smith, E. L., Harrington, K., Staehr, M., Masakayan, R., Jones, J., Long, T. J., Ng, K. Y., Ghoddusi, M., Purdon, T. J., Wang, X., Do, T., Pham, M. T., Brown, J. M., De Larrea, C. F., Olson, E., Peguero, E., Wang, P., Liu, H., Xu, Y., Garrett-Thomson, S. C. & 6 others, Almo, S. C., Wendel, H. G., Riviere, I., Liu, C., Sather, B. & Brentjens, R. J., Jan 1 2019, In : Science Translational Medicine. 11, 485, eaau7746.

Research output: Contribution to journal › Article

B-Cell Maturation Antigen
G-Protein-Coupled Receptors
T-Cell Antigen Receptor
Multiple Myeloma
Immunotherapy