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Matthew J. Gamble, Ph.D.

  • 1929 Citations
  • 16 h-Index
19992022
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Grants 2008 2022

The role of macroH2A variants in cancer and senescence

Gamble, M. J.

National Institutes of Health

5/4/12 → 3/31/22

Project: Research project

Neoplasms
Histones
Gene Expression
Genome
Poly Adenosine Diphosphate Ribose

Role of MacroH2A in Estrogen-Regulated Gene Expression

Gamble, M. J.

National Institutes of Health

3/5/08 → 3/4/10

Project: Research project

Estrogen Receptors
Estrogens
Chromatin
Gene Expression
NAD

Publications 1999 2019

  • 1929 Citations
  • 16 h-Index
  • 24 Article

The macroH2A1.2 histone variant links ATRX loss to alternative telomere lengthening

Kim, J., Sun, C., Tran, A. D., Chin, P. J., Ruiz, P. D., Wang, K., Gibbons, R. J., Gamble, M. J., Liu, Y. & Oberdoerffer, P., Mar 1 2019, In : Nature Structural and Molecular Biology. 26, 3, p. 213-219 7 p.

Research output: Contribution to journal › Article

Telomere Homeostasis
Histones
Telomere
Homologous Recombination
Epigenomics

Histone Variant MacroH2A1 Plays an Isoform-Specific Role in Suppressing Epithelial-Mesenchymal Transition

Hodge, D. Q., Cui, J., Gamble, M. J. & Guo, W., Dec 1 2018, In : Scientific Reports. 8, 1, 841.

Research output: Contribution to journal › Article

Epithelial-Mesenchymal Transition
Histones
Protein Isoforms
Epigenomics
Stem Cells

MacroH2A1 chromatin specification requires its docking domain and acetylation of H2B lysine 20

Ruiz, P. D. & Gamble, M. J., Dec 1 2018, In : Nature Communications. 9, 1, 5143.

Research output: Contribution to journal › Article

acetylation
Acetylation
chromatin
lysine
Lysine

S100A4 regulates macrophage invasion by distinct myosin-dependent and myosin-independent mechanisms

Dulianinova, N., Ruiz, P. D., Gamble, M. J., Backer, J. M. & Bresnicka, A. R., Mar 1 2018, In : Molecular Biology of the Cell. 29, 5, p. 632-642 11 p.

Research output: Contribution to journal › Article

Myosins
Macrophages
Nonmuscle Myosin Type IIA
Chemotaxis
Acetylation
59 Citations (Scopus)

MacroH2A1 and ATM Play Opposing Roles in Paracrine Senescence and the Senescence-Associated Secretory Phenotype

Chen, H., Ruiz, P. D., McKimpson, W. M., Novikov, L., Kitsis, R. N. & Gamble, M. J., Sep 3 2015, In : Molecular Cell. 59, 5, p. 719-731 13 p.

Research output: Contribution to journal › Article

Phenotype
Endoplasmic Reticulum Stress
Oncogenes
Genes
Histones