• 2267 Citations
  • 25 h-Index
1987 …2022
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Fingerprint Dive into the research topics where Kostantin Dobrenis is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 1 Similar Profiles
Neurons Medicine & Life Sciences
G(M2) Ganglioside Medicine & Life Sciences
Microglia Medicine & Life Sciences
Gangliosides Medicine & Life Sciences
Brain Medicine & Life Sciences
Type C Niemann-Pick Disease Medicine & Life Sciences
Glycosphingolipids Medicine & Life Sciences
Lysosomal Storage Diseases Medicine & Life Sciences

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Grants 2003 2022

Developmental Disabilities
Cell Engineering
Intellectual Disability
Research
leadership
Lysosomes
Autophagy
Neuroaxonal Dystrophies
Proteins
Dendrites
GM2 Gangliosidosis
Enzymes
Tay-Sachs Disease
Hematopoietic Stem Cells
Central Nervous System
Niemann-Pick Diseases
Type C Niemann-Pick Disease
Glycosphingolipids
Cholesterol
Therapeutics

Publications 1987 2018

  • 2267 Citations
  • 25 h-Index
  • 47 Article
9 Citations (Scopus)

Inhibition of Lysosome Membrane Recycling Causes Accumulation of Gangliosides that Contribute to Neurodegeneration

Boutry, M., Branchu, J., Lustremant, C., Pujol, C., Pernelle, J., Matusiak, R., Seyer, A., Poirel, M., Chu-Van, E., Pierga, A., Dobrenis, K., Puech, J. P., Caillaud, C., Durr, A., Brice, A., Colsch, B., Mochel, F., El Hachimi, K. H., Stevanin, G. & Darios, F., Jun 26 2018, In : Cell Reports. 23, 13, p. 3813-3826 14 p.

Research output: Contribution to journalArticle

Glycosphingolipids
Gangliosides
Lysosomes
Recycling
Membranes
2 Citations (Scopus)
Intellectual Disability
Nervous System
Spinal Cord
G(M2) Ganglioside
Phenotype
12 Citations (Scopus)

Cyclodextrin has conflicting actions on autophagy flux in vivo in brains of normal and Alzheimer model mice

Yang, D. S., Stavrides, P., Kumar, A., Jiang, Y., Mohan, P. S., Ohno, M., Dobrenis, K., Davidson, C. D., Saito, M., Pawlik, M., Huo, C., Walkley, S. U. & Nixon, R. A., Mar 1 2017, In : Human Molecular Genetics. 26, 5, p. 843-859 17 p., ddx001.

Research output: Contribution to journalArticle

Autophagy
Cyclodextrins
Cathepsin D
Brain
Lysosomes
6 Citations (Scopus)

Diversity of glycosphingolipid GM2 and cholesterol accumulation in NPC1 patient-specific iPSC-derived neurons

Trilck, M., Peter, F., Zheng, C., Frank, M., Dobrenis, K., Mascher, H., Rolfs, A. & Frech, M. J., Feb 15 2017, In : Brain Research. 1657, p. 52-61 10 p.

Research output: Contribution to journalArticle

Type C Niemann-Pick Disease
Glycosphingolipids
Cholesterol
Neurons
Mutation
3 Citations (Scopus)

N-butyldeoxynojirimycin delays motor deficits, cerebellar microgliosis, and Purkinje cell loss in a mouse model of mucolipidosis type IV

Boudewyn, L. C., Sikora, J., Kuchar, L., Ledvinova, J., Grishchuk, Y., Wang, S. L., Dobrenis, K. & Walkley, S. U., Sep 1 2017, In : Neurobiology of Disease. 105, p. 257-270 14 p.

Research output: Contribution to journalArticle

Mucolipidoses
Purkinje Cells
Glycosphingolipids
ceramide glucosyltransferase
Pathology