Projects per year
Fingerprint Dive into the research topics where Kostantin Dobrenis is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
- 1 Similar Profiles
Neurons
Medicine & Life Sciences
G(M2) Ganglioside
Medicine & Life Sciences
Microglia
Medicine & Life Sciences
Gangliosides
Medicine & Life Sciences
Brain
Medicine & Life Sciences
Type C Niemann-Pick Disease
Medicine & Life Sciences
Glycosphingolipids
Medicine & Life Sciences
Lysosomal Storage Diseases
Medicine & Life Sciences
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Grants 2003 2022
Support for the Rose F. Kennedy IDDRC
Dobrenis, K., Walkley, S. U., Molholm, S. & Molholm, S.
9/22/16 → 5/31/21
Project: Research project
Developmental Disabilities
Cell Engineering
Intellectual Disability
Research
leadership
Lysosomes
Autophagy
Neuroaxonal Dystrophies
Proteins
Dendrites
GM2 Gangliosidosis
Enzymes
Tay-Sachs Disease
Hematopoietic Stem Cells
Central Nervous System
Substrate Reduction Therapies for Niemann-Pick C Disease
Walkley, S. U., Dobrenis, K. & Walkley, S. U.
12/1/05 → 1/31/18
Project: Research project
Niemann-Pick Diseases
Type C Niemann-Pick Disease
Glycosphingolipids
Cholesterol
Therapeutics
Publications 1987 2018
- 2313 Citations
- 25 h-Index
- 47 Article
10
Citations
(Scopus)
Inhibition of Lysosome Membrane Recycling Causes Accumulation of Gangliosides that Contribute to Neurodegeneration
Boutry, M., Branchu, J., Lustremant, C., Pujol, C., Pernelle, J., Matusiak, R., Seyer, A., Poirel, M., Chu-Van, E., Pierga, A., Dobrenis, K., Puech, J. P., Caillaud, C., Durr, A., Brice, A., Colsch, B., Mochel, F., El Hachimi, K. H., Stevanin, G. & Darios, F., Jun 26 2018, In : Cell Reports. 23, 13, p. 3813-3826 14 p.Research output: Contribution to journal › Article
Glycosphingolipids
Gangliosides
Lysosomes
Recycling
Membranes
Pathobiology of Christianson syndrome: Linking disrupted endosomal-lysosomal function with intellectual disability and sensory impairments
Kerner-Rossi, M., Gulinello, M. E., Walkley, S. U. & Dobrenis, K., Jan 1 2018, (Accepted/In press) In : Neurobiology of Learning and Memory.Research output: Contribution to journal › Article
Intellectual Disability
Nervous System
Spinal Cord
G(M2) Ganglioside
Phenotype
12
Citations
(Scopus)
Cyclodextrin has conflicting actions on autophagy flux in vivo in brains of normal and Alzheimer model mice
Yang, D. S., Stavrides, P., Kumar, A., Jiang, Y., Mohan, P. S., Ohno, M., Dobrenis, K., Davidson, C. D., Saito, M., Pawlik, M., Huo, C., Walkley, S. U. & Nixon, R. A., Mar 1 2017, In : Human Molecular Genetics. 26, 5, p. 843-859 17 p., ddx001.Research output: Contribution to journal › Article
Autophagy
Cyclodextrins
Cathepsin D
Brain
Lysosomes
6
Citations
(Scopus)
Diversity of glycosphingolipid GM2 and cholesterol accumulation in NPC1 patient-specific iPSC-derived neurons
Trilck, M., Peter, F., Zheng, C., Frank, M., Dobrenis, K., Mascher, H., Rolfs, A. & Frech, M. J., Feb 15 2017, In : Brain Research. 1657, p. 52-61 10 p.Research output: Contribution to journal › Article
Type C Niemann-Pick Disease
Glycosphingolipids
Cholesterol
Neurons
Mutation
3
Citations
(Scopus)
N-butyldeoxynojirimycin delays motor deficits, cerebellar microgliosis, and Purkinje cell loss in a mouse model of mucolipidosis type IV
Boudewyn, L. C., Sikora, J., Kuchar, L., Ledvinova, J., Grishchuk, Y., Wang, S. L., Dobrenis, K. & Walkley, S. U., Sep 1 2017, In : Neurobiology of Disease. 105, p. 257-270 14 p.Research output: Contribution to journal › Article
Mucolipidoses
Purkinje Cells
Glycosphingolipids
ceramide glucosyltransferase
Pathology