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Antibodies Medicine & Life Sciences
Peptides Medicine & Life Sciences
Ebolavirus Medicine & Life Sciences
Glycoproteins Medicine & Life Sciences
Proteins Chemical Compounds
Viruses Chemical Compounds
Bacteriophages Medicine & Life Sciences
Conformations Chemical Compounds

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Grants 2010 2021

Monoclonal Antibodies
Antibodies
Therapeutics
Ebolavirus
Viruses

Engineered Dengue EDIIIs as Broad Immunogens

Lai, J. R.

National Institutes of Health

1/1/1712/31/18

Project: Research projectExploratory/Developmental Grants

Dengue
Infection
Serogroup
Glycoproteins
Subunit Vaccines

Consortium for Immunotherapeutics Against Viral Hemorrhagic Fevers

Lai, J. R. & Chandran, K.

National Institutes of Health

3/15/142/28/19

Project: Research projectResearch Program--Cooperative Agreements

Antibodies
Ebolavirus
Virology
Monoclonal Antibodies
Marburgvirus

Broadly Protective Bispecific Antibodies for Treatment of Ebola Virus Disease

Lai, J. R.

National Institutes of Health

7/5/166/30/17

Project: Research projectSmall Business Technology Transfer (STTR) Grants - Phase I

Ebola Hemorrhagic Fever
Bispecific Antibodies
Therapeutics
Antibodies
Epitopes

Methods to Identify High-Affinity Antibodies that Target Tumor-Associated Glycans

Lai, J. R.

National Institutes of Health

7/1/116/30/14

Project: Research projectExploratory/Developmental Grants

Neoplasm Antibodies
Antibody Affinity
Polysaccharides
Antibodies
Neoplasms

Publications 2001 2017

  • 1157 Citations
  • 20 h-Index
  • 49 Article
  • 1 Review article
3 Citations

Antibodies from a Human Survivor Define Sites of Vulnerability for Broad Protection against Ebolaviruses

Wec, A. Z. , Herbert, A. S. , Murin, C. D. , Nyakatura, E. K. , Abelson, D. M. , Fels, J. M. , He, S. , James, R. M. , de La Vega, M. A. , Zhu, W. , Bakken, R. R. , Goodwin, E. , Turner, H. L. , Jangra, R. K. , Zeitlin, L. , Qiu, X. , Lai, J. R. , Walker, L. M. , Ward, A. B. , Dye, J. M. & 2 others Chandran, K. & Bornholdt, Z. A. May 18 2017 In : Cell. 169, 5, p. 878-890.e15

Research output: Research - peer-reviewArticle

Ebolavirus
Glycoproteins
Antibodies
Fusion reactions
Ebola Hemorrhagic Fever

Bispecific antibodies for viral immunotherapy

Nyakatura, E. K., Soare, A. Y. & Lai, J. R. Apr 3 2017 In : Human vaccines & immunotherapeutics. 13, 4, p. 836-842 7 p.

Research output: Research - peer-reviewReview article

Bispecific Antibodies
Immunotherapy
Epitopes
Monoclonal Antibodies
Inflammation

Exploring human antimicrobial antibody responses on a single B cell level

Hofmann, D. & Lai, J. R. May 1 2017 In : Clinical and Vaccine Immunology. 24, 5, e00544

Research output: Research - peer-reviewArticle

Antibody Formation
B-Lymphocytes
Cells
Antibodies
Immunotherapy
Bacteriophages
Libraries
Polysaccharides
Antibodies
Display devices

Mechanistic and Fc requirements for inhibition of Sudan virus entry and in vivo protection by a synthetic antibody

Hofmann, D., Zak, S. E., Nyakatura, E. K., Mittler, E., Bakken, R. R., Chandran, K., Dye, J. M. & Lai, J. R. Oct 1 2017 In : Immunology Letters. 190, p. 289-295 7 p.

Research output: Research - peer-reviewArticle

Virus Internalization
Sudan
Viruses
Antibodies
Endosomes