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Jonathan R. Lai, Ph.D.

  • 1499 Citations
  • 23 h-Index
20012022
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  • 2 Similar Profiles
Ebolavirus Medicine & Life Sciences
Antibodies Medicine & Life Sciences
Viruses Chemical Compounds
Glycoproteins Medicine & Life Sciences
Peptides Medicine & Life Sciences
Marburgvirus Medicine & Life Sciences
Virus Internalization Medicine & Life Sciences
Bispecific Antibodies Medicine & Life Sciences

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Grants 2010 2022

A Trojan Horse bispecific antibody strategy for broad filovirus therapeutics

Lai, J. R. & Chandran, K.

National Institutes of Health

7/14/17 → 6/30/22

Project: Research project

Bispecific Antibodies
Monoclonal Antibodies
Ebolavirus
Epitopes
Sudan

Engineered, multispecific antibodies as broad anti-filovirus therapeutics

Lai, J. R.

National Institutes of Health

6/1/17 → 5/31/21

Project: Research project

Ebolavirus
Monoclonal Antibodies
Antibodies
Marburgvirus
Viruses

Consortium for Immunotherapeutics Against Viral Hemorrhagic Fevers

Lai, J. R. & Chandran, K.

National Institutes of Health

3/15/14 → 2/29/20

Project: Research project

Ebolavirus
Virology
Marburgvirus
Monoclonal Antibodies
Antibodies

Engineered Dengue EDIIIs as Broad Immunogens

Lai, J. R.

National Institutes of Health

1/1/17 → 12/31/18

Project: Research project

Dengue
Subunit Vaccines
Glycoproteins
Infection
Flavivirus

Broadly Protective Bispecific Antibodies for Treatment of Ebola Virus Disease

Lai, J. R.

National Institutes of Health

7/5/16 → 6/30/19

Project: Research project

Ebola Hemorrhagic Fever
Bispecific Antibodies
Ebolavirus
Viruses
Antibodies

Publications 2001 2019

  • 1499 Citations
  • 23 h-Index
  • 54 Article
  • 1 Chapter
  • 1 Review article

Isolation of Synthetic Antibodies Against BCL-2-Associated X Protein (BAX)

Dai, Z. & Lai, J. R., Jan 1 2019, Methods in Molecular Biology. Humana Press Inc., p. 351-357 7 p. (Methods in Molecular Biology; vol. 1877).

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Antibodies
Proteins
Immunoglobulin Fragments
Mitochondrial Membranes
Bacteriophages
13 Citations (Scopus)

A Role for Fc Function in Therapeutic Monoclonal Antibody-Mediated Protection against Ebola Virus

Gunn, B. M., Yu, W. H., Karim, M. M., Brannan, J. M., Herbert, A. S., Wec, A. Z., Halfmann, P. J., Fusco, M. L., Schendel, S. L., Gangavarapu, K., Krause, T., Qiu, X., He, S., Das, J., Suscovich, T. J., Lai, J. R., Chandran, K., Zeitlin, L., Crowe, J. E., Lauffenburger, D. & 6 others, Kawaoka, Y., Kobinger, G. P., Andersen, K. G., Dye, J. M., Saphire, E. O. & Alter, G., Aug 8 2018, In : Cell Host and Microbe. 24, 2, p. 221-233.e5

Research output: Contribution to journal › Article

Ebolavirus
Monoclonal Antibodies
Antibodies
Therapeutics
Neutralizing Antibodies
3 Citations (Scopus)

Design and evaluation of bi- and trispecific antibodies targeting multiple filovirus glycoproteins

Nyakatura, E. K., Zak, S. E., Wec, A. Z., Hofmann, D., Shulenin, S., Bakken, R. R., Javad Aman, M., Chandran, K., Dye, J. M. & Lai, J. R., Jan 1 2018, In : Journal of Biological Chemistry. 293, 16, p. 6201-6211 11 p.

Research output: Contribution to journal › Article

Ebolavirus
Bispecific Antibodies
Viruses
Glycoproteins
Marburgvirus
4 Citations (Scopus)

Engineered dengue virus domain III proteins elicit cross-neutralizing antibody responses in mice

Frei, J. C., Wirchnianski, A. S., Govero, J., Vergnolle, O. M., Dowd, K. A., Pierson, T. C., Kielian, M., Girvin, M. E., Diamond, M. S. & Lai, J. R., Sep 1 2018, In : Journal of Virology. 92, 18, e01023.

Research output: Contribution to journal › Article

Dengue virus
Dengue Virus
Neutralizing Antibodies
neutralizing antibodies
Antibody Formation
6 Citations (Scopus)

Protocadherin-1 is essential for cell entry by New World hantaviruses

Jangra, R., Herbert, A. S., Li, R., Jae, L. T., Kleinfelter, L. M., Slough, M. M., Barker, S. L., Guardado-Calvo, P., Román-Sosa, G., Dieterle, M. E., Kuehne, A. I., Muena, N. A., Wirchnianski, A. S., Nyakatura, E. K., Fels, J. M., Ng, M., Mittler, E-M., Pan, J., Bharrhan, S., Wec, A. Z. & 9 others, Lai, J. R., Sidhu, S. S., Tischler, N. D., Rey, F. A., Moffat, J., Brummelkamp, T. R., Wang, Z., Dye, J. M. & Chandran, K., Nov 1 2018, In : Nature. 563, 7732, p. 559-563 5 p.

Research output: Contribution to journal › Article

Hantavirus
Hantavirus Pulmonary Syndrome
Sin Nombre virus
Hantavirus Infections
South America