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  • 4 Similar Profiles
Peptides Medicine & Life Sciences
Antibodies Medicine & Life Sciences
Ebolavirus Medicine & Life Sciences
Glycoproteins Medicine & Life Sciences
Bulimia Chemical Compounds
Proteins Medicine & Life Sciences
Viruses Medicine & Life Sciences
Infection Medicine & Life Sciences

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Grants 2010 2021

Monoclonal Antibodies
Antibodies
Ebolavirus
Viruses
Marburgvirus

Engineered Dengue EDIIIs as Broad Immunogens

Lai, J. R.

National Institutes of Health

1/1/1712/31/18

Project: Research projectExploratory/Developmental Grants

Dengue
Infection
Serogroup
Glycoproteins
Subunit Vaccines

Consortium for Immunotherapeutics Against Viral Hemorrhagic Fevers

Lai, J. R. & Chandran, K.

National Institutes of Health

3/15/142/28/19

Project: Research projectResearch Program--Cooperative Agreements

Antibodies
Ebolavirus
Virology
Monoclonal Antibodies
Marburgvirus

Broadly Protective Bispecific Antibodies for Treatment of Ebola Virus Disease

Lai, J. R.

National Institutes of Health

7/5/166/30/17

Project: Research projectSmall Business Technology Transfer (STTR) Grants - Phase I

Ebola Hemorrhagic Fever
Bispecific Antibodies
Antibodies
Epitopes
Glycoproteins

Methods to Identify High-Affinity Antibodies that Target Tumor-Associated Glycans

Lai, J. R.

National Institutes of Health

7/1/116/30/14

Project: Research projectExploratory/Developmental Grants

Neoplasm Antibodies
Antibody Affinity
Polysaccharides
Antibodies
Neoplasms

Publications 2001 2017

  • 1114 Citations
  • 19 h-Index
  • 47 Article
  • 1 Review article
2 Citations

Antibodies from a Human Survivor Define Sites of Vulnerability for Broad Protection against Ebolaviruses

Wec, A. Z. , Herbert, A. S. , Murin, C. D. , Nyakatura, E. K. , Abelson, D. M. , Fels, J. M. , He, S. , James, R. M. , de La Vega, M. A. , Zhu, W. , Bakken, R. R. , Goodwin, E. , Turner, H. L. , Jangra, R. K. , Zeitlin, L. , Qiu, X. , Lai, J. R. , Walker, L. M. , Ward, A. B. , Dye, J. M. & 2 others Chandran, K. & Bornholdt, Z. A. May 18 2017 In : Cell. 169, 5, p. 878-890.e15

Research output: Contribution to journalArticle

Ebolavirus
Glycoproteins
Antibodies
Fusion reactions
Infection

Bispecific antibodies for viral immunotherapy

Nyakatura, E. K., Soare, A. Y. & Lai, J. R. Apr 3 2017 In : Human vaccines & immunotherapeutics. 13, 4, p. 836-842 7 p.

Research output: Contribution to journalReview article

Bispecific Antibodies
Immunotherapy
Epitopes
Monoclonal Antibodies
Inflammation

Exploring human antimicrobial antibody responses on a single B cell level

Hofmann, D. & Lai, J. R. May 1 2017 In : Clinical and Vaccine Immunology. 24, 5, e00544

Research output: Contribution to journalArticle

Antibody Formation
B-Lymphocytes
Castration
Immunotherapy
Organism Cloning
15 Citations

Antibody Treatment of Ebola and Sudan Virus Infection via a Uniquely Exposed Epitope within the Glycoprotein Receptor-Binding Site

Howell, K. A. , Qiu, X. , Brannan, J. M. , Bryan, C. , Davidson, E. , Holtsberg, F. W. , Wec, A. Z. , Shulenin, S. , Biggins, J. E. , Douglas, R. , Enterlein, S. G. , Turner, H. L. , Pallesen, J. , Murin, C. D. , He, S. , Kroeker, A. , Vu, H. , Herbert, A. S. , Fusco, M. L. , Nyakatura, E. K. & 11 others Lai, J. R., Keck, Z. Y., Foung, S. K. H., Saphire, E. O., Zeitlin, L., Ward, A. B., Chandran, K., Doranz, B. J., Kobinger, G. P., Dye, J. M. & Aman, M. J. May 17 2016 In : Cell Reports. 15, 7, p. 1514-1526 13 p.

Research output: Contribution to journalArticle

Ebolavirus
Epitopes
Glycoproteins
Binding Sites
Antibodies
10 Citations

A "Trojan horse" bispecific-antibody strategy for broad protection against ebolaviruses

Wec, A. Z., Nyakatura, E. K., Herbert, A. S., Howell, K. A., Holtsberg, F. W., Bakken, R. R., Mittler, E., Christin, J. R., Shulenin, S., Jangra, R. K., Bharrhan, S., Kuehne, A. I., Bornholdt, Z. A., Flyak, A. I., Saphire, E. O., Crowe, J. E., Aman, M. J., Dye, J. M., Lai, J. R. & Chandran, K. Oct 21 2016 In : Science. 354, 6310, p. 350-354 5 p.

Research output: Contribution to journalArticle

Ebolavirus
Bispecific Antibodies
Monoclonal Antibodies
Endosomes
Virion