Projects per year
Fingerprint Dive into the research topics where Edward L. Schwartz is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
Thymidine Phosphorylase
Medicine & Life Sciences
Interferons
Medicine & Life Sciences
Fluorouracil
Medicine & Life Sciences
Leukemia
Medicine & Life Sciences
Thioguanine
Medicine & Life Sciences
2-Acetylaminofluorene
Medicine & Life Sciences
HL-60 Cells
Medicine & Life Sciences
Colon
Medicine & Life Sciences
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Grants 1992 2024
Vulnerability of SCLC based on bi-allelic genetic inactivation of RB1 and TP53
4/12/19 → 3/31/24
Project: Research project
Small Cell Lung Carcinoma
Drug Therapy
Heterografts
Neoplasms
Ubiquitination
Interactions of the angiopoietin and PD-ECGF pathways in tumor angiogenesis
7/9/12 → 5/31/18
Project: Research project
Angiopoietins
Thymidine Phosphorylase
Angiogenesis Inducing Agents
Neoplasms
Neuroendocrine Tumors
docetaxel
Microtubule-Organizing Center
Microtubules
Endothelial Cells
Cell Movement
Thymidine Phosphorylase
Phosphorylases
Deoxyribose
Endothelial Cells
Neoplasms
Thymidine Phosphorylase
Fluorouracil
Interferons
Colon
Fluorodeoxyuridylate
Publications 1977 2019
1
Citation
(Scopus)
Lysosome Membrane Permeabilization and Disruption of the Molecular Target of Rapamycin (mTOR)-Lysosome Interaction Are Associated with the Inhibition of Lung Cancer Cell Proliferation by a Chloroquinoline Analog
Sironi, J., Aranda, E., Nordstroem, L. R. & Schwartz, E. L., Jan 1 2019, In : Molecular Pharmacology. 95, 1, p. 127-138 12 p.Research output: Contribution to journal › Article
Autophagy
Sirolimus
Lysosomes
Lung Neoplasms
Cell Proliferation
11
Citations
(Scopus)
Discovery of autophagy inhibitors with antiproliferative activity in lung and pancreatic cancer cells
Nordstroem, L. R., Sironi, J., Aranda, E., Maisonet, J., Perez-Soler, R., Wu, P. & Schwartz, E. L., Feb 12 2015, In : ACS Medicinal Chemistry Letters. 6, 2, p. 134-139 6 p.Research output: Contribution to journal › Article
Autophagy
Chloroquine
Pancreatic Neoplasms
Hydroxychloroquine
Lung Neoplasms
36
Citations
(Scopus)
RICTOR amplification defines a novel subset of patients with lung cancer who may benefit from treatment with mTORC1/2 inhibitors
Cheng, H., Zou, Y., Ross, J. S., Wang, K., Liu, X., Halmos, B., Ali, S. M., Liu, H., Verma, A. K., Montagna, C., Chachoua, A., Goel, S., Schwartz, E. L., Zhu, C., Shan, J., Yu, Y., Gritsman, K., Yelensky, R., Lipson, D., Otto, G. & 5 others, , Dec 1 2015, In : Cancer Discovery. 5, 12, p. 1262-1270 9 p.Research output: Contribution to journal › Article
Lung Neoplasms
Atlases
Therapeutics
Neoplasms
Genome
6
Citations
(Scopus)
Stilbene 5c, a microtubule poison with vascular disrupting properties that induces multiple modes of growth arrest and cell death
Alotaibi, M. R., Asnake, B., Di, X., Beckman, M. J., Durrant, D., Simoni, D., Baruchello, R., Lee, R. M., Schwartz, E. L. & Gewirtz, D. A., 2013, In : Biochemical Pharmacology. 86, 12, p. 1688-1698 11 p.Research output: Contribution to journal › Article
Poisons
Cell death
Microtubules
Blood Vessels
Cell Death
60
Citations
(Scopus)
The autophagy inhibitor chloroquine overcomes the innate resistance of wild-type EGFR non-small-cell lung cancer cells to erlotinib
Zou, Y., Ling, Y. H., Sironi, J., Schwartz, E. L., Perez-Soler, R. & Piperdi, B., Jun 2013, In : Journal of Thoracic Oncology. 8, 6, p. 693-702 10 p.Research output: Contribution to journal › Article
Autophagy
Chloroquine
Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
Neoplasms