Physiology & Biophysics

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Proteins Medicine & Life Sciences
Heme Chemical Compounds
Membranes Medicine & Life Sciences
Hemoglobins Medicine & Life Sciences
Ligands Medicine & Life Sciences
Oxygen Medicine & Life Sciences
Microtubules Medicine & Life Sciences
Carbon Monoxide Chemical Compounds

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Projects 1975 2020

Dioxygenases
Tryptophan
Enzymes
Degradation
Neurodegenerative diseases

MECHANISM OF MICROTUBULE DYNAMICS REGULATION BY KINESINS

Sosa, H. J.

National Institutes of Health

3/1/152/28/19

Project: Research projectResearch Project

Kinesin
Microtubules
Tubulin
Polymers
Centrioles
Falciparum Malaria
Plasmodium falciparum
Parasites
purine
Equilibrative Nucleoside Transporter 1

Research Output 1965 2018

The mitochondrial 2-oxoadipate and 2-oxoglutarate dehydrogenase complexes share their E2 and E3 components for their function and both generate reactive oxygen species

Nemeria, N. S., Gerfen, G., Nareddy, P. R., Yang, L., Zhang, X., Szostak, M. & Jordan, F. Feb 1 2018 In : Free Radical Biology and Medicine. 115, p. 136-145 10 p.

Research output: Research - peer-reviewArticle

Ketoglutarate Dehydrogenase Complex
Reactive Oxygen Species
Oxidoreductases
Thiamine Pyrophosphate
alpha-ketoglutaric acid

Use of single molecule fluorescence polarization microscopy to study protein conformation and dynamics of kinesin–microtubule complexes

Benoit, M. P. M. H. & Sosa, H. 2018 Methods in Molecular Biology. Humana Press Inc., Vol. 1665, p. 199-216 18 p. (Methods in Molecular Biology; vol. 1665)

Research output: ResearchChapter

Polarization Microscopy
Kinesin
Protein Conformation
Fluorescence Polarization
Fluorescence Microscopy
2 Citations

Crystal structure of CO-bound cytochrome c oxidase determined by serial femtosecond X-ray crystallography at room temperature

Ishigami, I., Zatsepin, N. A., Hikita, M., Conrad, C. E., Nelson, G., Coe, J. D., Basu, S., Grant, T. D., Seaberg, M. H., Sierra, R. G., Hunter, M. S., Fromme, P., Fromme, R., Yeh, S. R. & Rousseau, D. L. Jul 25 2017 In : Proceedings of the National Academy of Sciences of the United States of America. 114, 30, p. 8011-8016 6 p.

Research output: Research - peer-reviewArticle

X ray crystallography
Electron Transport Complex IV
Carbon Monoxide
Crystal structure
Temperature