Physiology & Biophysics

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Heme Chemical Compounds
Proteins Medicine & Life Sciences
Membranes Medicine & Life Sciences
Hemoglobins Medicine & Life Sciences
Ligands Medicine & Life Sciences
Oxygen Medicine & Life Sciences
Microtubules Medicine & Life Sciences
Carbon Monoxide Chemical Compounds

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Projects 1975 2020

Dioxygenases
Tryptophan
Enzymes
Degradation
Neurodegenerative diseases

MECHANISM OF MICROTUBULE DYNAMICS REGULATION BY KINESINS

Sosa, H. J.

National Institutes of Health

3/1/152/28/19

Project: Research projectResearch Project

Kinesin
Microtubules
Tubulin
Polymers
Centrioles
Falciparum Malaria
Plasmodium falciparum
Parasites
purine
Equilibrative Nucleoside Transporter 1

Research Output 1965 2018

Use of single molecule fluorescence polarization microscopy to study protein conformation and dynamics of kinesin–microtubule complexes

Benoit, M. P. M. H. & Sosa, H. 2018 Methods in Molecular Biology. Humana Press Inc., Vol. 1665, p. 199-216 18 p. (Methods in Molecular Biology; vol. 1665)

Research output: ResearchChapter

Polarization Microscopy
Kinesin
Protein Conformation
Fluorescence Polarization
Fluorescence Microscopy

Crystal structure of CO-bound cytochrome c oxidase determined by serial femtosecond X-ray crystallography at room temperature

Ishigami, I., Zatsepin, N. A., Hikita, M., Conrad, C. E., Nelson, G., Coe, J. D., Basu, S., Grant, T. D., Seaberg, M. H., Sierra, R. G., Hunter, M. S., Fromme, P., Fromme, R., Yeh, S. R. & Rousseau, D. L. Jul 25 2017 In : Proceedings of the National Academy of Sciences of the United States of America. 114, 30, p. 8011-8016 6 p.

Research output: Research - peer-reviewArticle

X ray crystallography
Electron Transport Complex IV
Carbon Monoxide
Crystal structure
Temperature

HbE/β-Thalassemia and Oxidative Stress: The Key to Pathophysiological Mechanisms and Novel Therapeutics

Hirsch, R. E., Sibmooh, N., Fucharoen, S. & Friedman, J. M. May 10 2017 In : Antioxidants and Redox Signaling. 26, 14, p. 794-813 20 p.

Research output: Research - peer-reviewReview article

beta-Thalassemia
Oxidative Stress
Morbidity
Therapeutics
Oxidative stress