T-Maze performance after developmental exposure to 19F tagged 5-HTP in chicks

Sherry Dingman, Laurie Nash, Jeremy Hogan, Craig A. Branch

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Chicks were used as a model to investigate behavioral effects of administering a new compound intended for use with magnetic resonance. The compound has multiple 19F atom tags covalently bonded to the indole ring of 5-hydroxytryptophan (PF-5HTP), the immediate precursor to the neurotransmitter serotonin. On incubation Day 17, 5μg of PF-5-HTP, an equivalent amount of 5-HTP, or just 200 μL of the weak phosphate buffered saline (PBS) vehicle was injected into the airsac of each egg. Three days after hatching, chicks were isolated at the top of a simple T-Maze which, when traversed correctly, enabled them to return to their brood mates. A second trial in the T-Maze was conducted about three hours later. The brief period of isolation at the start of a trial causes social distress in chicks who are reinforced by returning to the brood. The task was selected as being sensitive to functioning of the serotonin pathways whose development might be altered by administering the compound during brain development. Repeated-measures analysis of variance yielded a statistically significant main effect for trial within groups, but no significant difference between injection groups. Administering a low dose of the fluorine tagged compound during development did not impair performance on this T-maze task.

Original languageEnglish (US)
Pages (from-to)793-798
Number of pages6
JournalPerceptual and Motor Skills
Volume99
Issue number3 I
StatePublished - Dec 2004
Externally publishedYes

Fingerprint

5-Hydroxytryptophan
Serotonin
Fluorine Compounds
Ovum
Neurotransmitter Agents
Analysis of Variance
Magnetic Resonance Spectroscopy
Phosphates
Injections
Brain

ASJC Scopus subject areas

  • Psychology(all)
  • Experimental and Cognitive Psychology

Cite this

T-Maze performance after developmental exposure to 19F tagged 5-HTP in chicks. / Dingman, Sherry; Nash, Laurie; Hogan, Jeremy; Branch, Craig A.

In: Perceptual and Motor Skills, Vol. 99, No. 3 I, 12.2004, p. 793-798.

Research output: Contribution to journalArticle

Dingman, Sherry ; Nash, Laurie ; Hogan, Jeremy ; Branch, Craig A. / T-Maze performance after developmental exposure to 19F tagged 5-HTP in chicks. In: Perceptual and Motor Skills. 2004 ; Vol. 99, No. 3 I. pp. 793-798.
@article{e815500c15634c7c8325c4585fa9b3d0,
title = "T-Maze performance after developmental exposure to 19F tagged 5-HTP in chicks",
abstract = "Chicks were used as a model to investigate behavioral effects of administering a new compound intended for use with magnetic resonance. The compound has multiple 19F atom tags covalently bonded to the indole ring of 5-hydroxytryptophan (PF-5HTP), the immediate precursor to the neurotransmitter serotonin. On incubation Day 17, 5μg of PF-5-HTP, an equivalent amount of 5-HTP, or just 200 μL of the weak phosphate buffered saline (PBS) vehicle was injected into the airsac of each egg. Three days after hatching, chicks were isolated at the top of a simple T-Maze which, when traversed correctly, enabled them to return to their brood mates. A second trial in the T-Maze was conducted about three hours later. The brief period of isolation at the start of a trial causes social distress in chicks who are reinforced by returning to the brood. The task was selected as being sensitive to functioning of the serotonin pathways whose development might be altered by administering the compound during brain development. Repeated-measures analysis of variance yielded a statistically significant main effect for trial within groups, but no significant difference between injection groups. Administering a low dose of the fluorine tagged compound during development did not impair performance on this T-maze task.",
author = "Sherry Dingman and Laurie Nash and Jeremy Hogan and Branch, {Craig A.}",
year = "2004",
month = "12",
language = "English (US)",
volume = "99",
pages = "793--798",
journal = "Perceptual and Motor Skills",
issn = "0031-5125",
publisher = "Ammons Scientific Ltd",
number = "3 I",

}

TY - JOUR

T1 - T-Maze performance after developmental exposure to 19F tagged 5-HTP in chicks

AU - Dingman, Sherry

AU - Nash, Laurie

AU - Hogan, Jeremy

AU - Branch, Craig A.

PY - 2004/12

Y1 - 2004/12

N2 - Chicks were used as a model to investigate behavioral effects of administering a new compound intended for use with magnetic resonance. The compound has multiple 19F atom tags covalently bonded to the indole ring of 5-hydroxytryptophan (PF-5HTP), the immediate precursor to the neurotransmitter serotonin. On incubation Day 17, 5μg of PF-5-HTP, an equivalent amount of 5-HTP, or just 200 μL of the weak phosphate buffered saline (PBS) vehicle was injected into the airsac of each egg. Three days after hatching, chicks were isolated at the top of a simple T-Maze which, when traversed correctly, enabled them to return to their brood mates. A second trial in the T-Maze was conducted about three hours later. The brief period of isolation at the start of a trial causes social distress in chicks who are reinforced by returning to the brood. The task was selected as being sensitive to functioning of the serotonin pathways whose development might be altered by administering the compound during brain development. Repeated-measures analysis of variance yielded a statistically significant main effect for trial within groups, but no significant difference between injection groups. Administering a low dose of the fluorine tagged compound during development did not impair performance on this T-maze task.

AB - Chicks were used as a model to investigate behavioral effects of administering a new compound intended for use with magnetic resonance. The compound has multiple 19F atom tags covalently bonded to the indole ring of 5-hydroxytryptophan (PF-5HTP), the immediate precursor to the neurotransmitter serotonin. On incubation Day 17, 5μg of PF-5-HTP, an equivalent amount of 5-HTP, or just 200 μL of the weak phosphate buffered saline (PBS) vehicle was injected into the airsac of each egg. Three days after hatching, chicks were isolated at the top of a simple T-Maze which, when traversed correctly, enabled them to return to their brood mates. A second trial in the T-Maze was conducted about three hours later. The brief period of isolation at the start of a trial causes social distress in chicks who are reinforced by returning to the brood. The task was selected as being sensitive to functioning of the serotonin pathways whose development might be altered by administering the compound during brain development. Repeated-measures analysis of variance yielded a statistically significant main effect for trial within groups, but no significant difference between injection groups. Administering a low dose of the fluorine tagged compound during development did not impair performance on this T-maze task.

UR - http://www.scopus.com/inward/record.url?scp=12944274828&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=12944274828&partnerID=8YFLogxK

M3 - Article

C2 - 15648472

AN - SCOPUS:12944274828

VL - 99

SP - 793

EP - 798

JO - Perceptual and Motor Skills

JF - Perceptual and Motor Skills

SN - 0031-5125

IS - 3 I

ER -