Risk factors for a first febrile seizure

A matched case-control study

A. T. Berg, Shlomo Shinnar, E. D. Shapiro, M. E. Salomon, E. F. Crain, W. A. Hauser

Research output: Contribution to journalArticle

131 Citations (Scopus)

Abstract

We conducted a matched case-control study to identify risk factors for first febrile seizures, with special emphasis on characteristics of the acute illness episode. Cases were identified through hospital emergency departments; controls were identified through outpatient clinics and emergency departments. Sixty-nine children with first febrile seizures and no history of previous unprovoked seizures were matched for age (±6 months), site of routine pediatric care, and date of visit (±2 weeks) with 1 or 2 febrile controls who had no history of previous febrile or unprovoked seizures. Medical records for the index visit were reviewed, and parents were interviewed by telephone. Illness characteristics examined included height of temperature, type of underlying illness, contact with a physician during the illness but before the index visit, and use of acetaminophen or decongestants. Family history of febrile and of unprovoked seizures, sociodemographic characteristics, daycare use, and selected pre-and perinatal variables were also studied. On multivariable analysis, significant independent risk factors were height of temperature, history of febrile seizures in a first-or in a higher degree relative. Gastroenteritis as the underlying illness had a significant inverse (i.e., protective) association with febrile seizures. Maternal smoking during pregnancy was a marginally significant predictor of febrile seizures.

Original languageEnglish (US)
Pages (from-to)334-341
Number of pages8
JournalEpilepsia
Volume36
Issue number4
DOIs
StatePublished - 1995

Fingerprint

Febrile Seizures
Case-Control Studies
Hospital Emergency Service
Seizures
Fever
Nasal Decongestants
Temperature
Hospital Departments
Gastroenteritis
Acetaminophen
Ambulatory Care Facilities
Telephone
Medical Records
Parents
Smoking
Mothers
Pediatrics
Physicians
Pregnancy

Keywords

  • Acute illness episode
  • Family history
  • Febrile seizures
  • Fever
  • Gastroenteritis
  • Maternal smoking during pregnancy
  • Risk factors

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Berg, A. T., Shinnar, S., Shapiro, E. D., Salomon, M. E., Crain, E. F., & Hauser, W. A. (1995). Risk factors for a first febrile seizure: A matched case-control study. Epilepsia, 36(4), 334-341. https://doi.org/10.1111/j.1528-1157.1995.tb01006.x

Risk factors for a first febrile seizure : A matched case-control study. / Berg, A. T.; Shinnar, Shlomo; Shapiro, E. D.; Salomon, M. E.; Crain, E. F.; Hauser, W. A.

In: Epilepsia, Vol. 36, No. 4, 1995, p. 334-341.

Research output: Contribution to journalArticle

Berg, AT, Shinnar, S, Shapiro, ED, Salomon, ME, Crain, EF & Hauser, WA 1995, 'Risk factors for a first febrile seizure: A matched case-control study', Epilepsia, vol. 36, no. 4, pp. 334-341. https://doi.org/10.1111/j.1528-1157.1995.tb01006.x
Berg, A. T. ; Shinnar, Shlomo ; Shapiro, E. D. ; Salomon, M. E. ; Crain, E. F. ; Hauser, W. A. / Risk factors for a first febrile seizure : A matched case-control study. In: Epilepsia. 1995 ; Vol. 36, No. 4. pp. 334-341.
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