Recognition of a lipid antigen by CD1-restricted αβ+ T cells

Evan M. Beckman, Steven A. Porcelli, Craig T. Morita, Samuel M. Behar, Stephen T. Furlong, Michael B. Brenner

Research output: Contribution to journalArticle

819 Citations (Scopus)

Abstract

MAJOR histocompatibility complex (MHC) class I and class II molecules bind immunogenic peptides and present them to lymphocytes bearing the αβ T-cell antigen receptor (TCR)1-4. An analogous antigen-presenting function also has been proposed for the non-MHC-encoded CD1 molecules5, a family of non-polymorphic, β2-microglobulin-associated glycoproteins expressed on most professional antigen-presenting cells9-11. In support of this hypothesis, CD1 molecules are recognized by selected CD4-D8- αβ or γδTCR+ T-cell clones12-14, and we have recently shown that CD1 molecules restrict the recognition of foreign microbial antigens by αβTCR+ T cells10. But the substantial structural divergence of CD1 from MHC class I and class II molecules7, raises the possibility that the antigens presented by the CD1 system may differ fundamentally from those presented by MHC-encoded molecules. Here we report that a purified CD1b-restricted antigen of Mycobacterium tuberculosis presented to αβTCR+ T cells is mycolic acid, a family of α-branched, β-hydroxy, long-chain fatty acids found in mycobacteria15,16. This example of non-protein microbial antigen recognition suggests that αβTCR+ T cells recognize a broader range of antigens than previously appreciated and that at least one member of the CD1 family has evolved the ability to present lipid antigens.

Original languageEnglish (US)
Pages (from-to)691-694
Number of pages4
JournalNature
Volume372
Issue number6507
StatePublished - Dec 15 1994
Externally publishedYes

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CD1 Antigens
T-Cell Antigen Receptor
Major Histocompatibility Complex
T-Lymphocytes
Lipids
Antigens
Mycolic Acids
Aptitude
Mycobacterium tuberculosis
Glycoproteins
Fatty Acids
Lymphocytes
Peptides

ASJC Scopus subject areas

  • General

Cite this

Beckman, E. M., Porcelli, S. A., Morita, C. T., Behar, S. M., Furlong, S. T., & Brenner, M. B. (1994). Recognition of a lipid antigen by CD1-restricted αβ+ T cells. Nature, 372(6507), 691-694.

Recognition of a lipid antigen by CD1-restricted αβ+ T cells. / Beckman, Evan M.; Porcelli, Steven A.; Morita, Craig T.; Behar, Samuel M.; Furlong, Stephen T.; Brenner, Michael B.

In: Nature, Vol. 372, No. 6507, 15.12.1994, p. 691-694.

Research output: Contribution to journalArticle

Beckman, EM, Porcelli, SA, Morita, CT, Behar, SM, Furlong, ST & Brenner, MB 1994, 'Recognition of a lipid antigen by CD1-restricted αβ+ T cells', Nature, vol. 372, no. 6507, pp. 691-694.
Beckman EM, Porcelli SA, Morita CT, Behar SM, Furlong ST, Brenner MB. Recognition of a lipid antigen by CD1-restricted αβ+ T cells. Nature. 1994 Dec 15;372(6507):691-694.
Beckman, Evan M. ; Porcelli, Steven A. ; Morita, Craig T. ; Behar, Samuel M. ; Furlong, Stephen T. ; Brenner, Michael B. / Recognition of a lipid antigen by CD1-restricted αβ+ T cells. In: Nature. 1994 ; Vol. 372, No. 6507. pp. 691-694.
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