Normal fasting-state levels of serum cholyl-conjugated bile acids in Gilbert's syndrome: An aid to the diagnosis

J. M. Vierling, P. D. Berk, A. F. Hofmann, J. F. Martin, Allan W. Wolkoff, B. F. Scharschmidt

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Fasting levels of cholic acid conjugates were determined by radioimmunoassay in the serum of 24 patients with extensively documented Gilbert's syndrome and in 98 healthy controls without unconjugated hyperbilirubinemia. The Gilbert's syndrome patients studied included all three types, as determined from studies of the plasma disappearance kinetics of sulfobromophthalein and indocyanine green. Although patients with structural liver disease severe enough to produce hyperbilirubinemia almost invariably have elevated fasting serum levels of cholic acid conjugates, values were normal in each of the Gilbert's syndrome patients, including patients with metabolic abnormalities in sulfobromophthalein and indocyanine green transport. It is concluded that the measurement of fasting serum levels of cholic acid conjugates is a useful adjunct to the diagnosis of Gilbert's syndrome.

Original languageEnglish (US)
Pages (from-to)340-343
Number of pages4
JournalHepatology
Volume2
Issue number3
StatePublished - 1982

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Gilbert Disease
Bile Acids and Salts
Fasting
Cholic Acid
Sulfobromophthalein
Serum
Indocyanine Green
Hyperbilirubinemia
Radioimmunoassay
Liver Diseases
Reference Values

ASJC Scopus subject areas

  • Hepatology

Cite this

Vierling, J. M., Berk, P. D., Hofmann, A. F., Martin, J. F., Wolkoff, A. W., & Scharschmidt, B. F. (1982). Normal fasting-state levels of serum cholyl-conjugated bile acids in Gilbert's syndrome: An aid to the diagnosis. Hepatology, 2(3), 340-343.

Normal fasting-state levels of serum cholyl-conjugated bile acids in Gilbert's syndrome : An aid to the diagnosis. / Vierling, J. M.; Berk, P. D.; Hofmann, A. F.; Martin, J. F.; Wolkoff, Allan W.; Scharschmidt, B. F.

In: Hepatology, Vol. 2, No. 3, 1982, p. 340-343.

Research output: Contribution to journalArticle

Vierling, JM, Berk, PD, Hofmann, AF, Martin, JF, Wolkoff, AW & Scharschmidt, BF 1982, 'Normal fasting-state levels of serum cholyl-conjugated bile acids in Gilbert's syndrome: An aid to the diagnosis', Hepatology, vol. 2, no. 3, pp. 340-343.
Vierling, J. M. ; Berk, P. D. ; Hofmann, A. F. ; Martin, J. F. ; Wolkoff, Allan W. ; Scharschmidt, B. F. / Normal fasting-state levels of serum cholyl-conjugated bile acids in Gilbert's syndrome : An aid to the diagnosis. In: Hepatology. 1982 ; Vol. 2, No. 3. pp. 340-343.
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