### Abstract

Misclassification can arise in the case-control setting in both the risk factor of interest, and in a potential confounder. If true status is not ascertainable, but an independent replicated sample is available, adjusted maximum likelihood estimates of the individual binomial proportions can be obtained, and hence a relative risk estimate of the Mantel-Haenszel type constructed. An interval estimate on the latter can be calculated using the asymptotic properties of the likelihood function. The method is illustrated by application to a case-control study of breast cancer risk and such lifestyle attributes as diet, smoking and alcohol consumption, in which misclassification was anticipated and consequently repeatability data were collected.

Original language | English (US) |
---|---|

Pages (from-to) | 1529-1536 |

Number of pages | 8 |

Journal | Statistics in Medicine |

Volume | 8 |

Issue number | 12 |

State | Published - 1989 |

Externally published | Yes |

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### ASJC Scopus subject areas

- Epidemiology

### Cite this

*Statistics in Medicine*,

*8*(12), 1529-1536.

**Misclassification in more than one factor in a case-control study : A combination of Mantel-Haenszel and maximum likelihood approaches.** / Duffy, S. W.; Rohan, Thomas E.; Day, N. E.

Research output: Contribution to journal › Article

*Statistics in Medicine*, vol. 8, no. 12, pp. 1529-1536.

}

TY - JOUR

T1 - Misclassification in more than one factor in a case-control study

T2 - A combination of Mantel-Haenszel and maximum likelihood approaches

AU - Duffy, S. W.

AU - Rohan, Thomas E.

AU - Day, N. E.

PY - 1989

Y1 - 1989

N2 - Misclassification can arise in the case-control setting in both the risk factor of interest, and in a potential confounder. If true status is not ascertainable, but an independent replicated sample is available, adjusted maximum likelihood estimates of the individual binomial proportions can be obtained, and hence a relative risk estimate of the Mantel-Haenszel type constructed. An interval estimate on the latter can be calculated using the asymptotic properties of the likelihood function. The method is illustrated by application to a case-control study of breast cancer risk and such lifestyle attributes as diet, smoking and alcohol consumption, in which misclassification was anticipated and consequently repeatability data were collected.

AB - Misclassification can arise in the case-control setting in both the risk factor of interest, and in a potential confounder. If true status is not ascertainable, but an independent replicated sample is available, adjusted maximum likelihood estimates of the individual binomial proportions can be obtained, and hence a relative risk estimate of the Mantel-Haenszel type constructed. An interval estimate on the latter can be calculated using the asymptotic properties of the likelihood function. The method is illustrated by application to a case-control study of breast cancer risk and such lifestyle attributes as diet, smoking and alcohol consumption, in which misclassification was anticipated and consequently repeatability data were collected.

UR - http://www.scopus.com/inward/record.url?scp=0024801527&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024801527&partnerID=8YFLogxK

M3 - Article

VL - 8

SP - 1529

EP - 1536

JO - Statistics in Medicine

JF - Statistics in Medicine

SN - 0277-6715

IS - 12

ER -