Human T-cell lymphotropic virus type I and severe neoplasia of the cervix in Jamaica

Howard Strickler, C. Rattray, C. Escoffery, A. Manns, M. H. Schiffman, C. Brown, B. Cranston, B. Hanchard, J. M. Palefsky, W. A. Blatiner

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Human T-cell lymphotropic virus type I (HTLV-I) was associated with carcinoma of the cervix in Japan in a recent study that compared hospital cases with healthy population-based controls. To test this relationship in women more alike for cervical neoplasia risk factors (including sexual behavior and human papilloma virus; HPV), we enrolled consecutive patients from a colposcopy clinic in Kingston, Jamaica (an HTLV-I endemic area). Patients underwent Pap smear, colposcopy, biopsy and cervical swab for detection of HPV by polymerase chain reaction. Cases were defined as women with CIN-3 or invasive cancer (CIN-3/CA). Controls included all patients with either CIN-I or koilocytotic atypia, atypical squamous cells of undetermined significance or benign cervical pathology (all but one had at least inflammatory changes). Patients with CIN-2 were excluded to minimize risk of case-control misclassification. Cases were much more likely to be HTLV-I seropositive than controls. Although mean age differed significantly between cases (mean age = 39 years) and controls (mean age = 33 years), control for age did not explain the relation of CIN-3/CA with HTLV-I. Among HPV DNA positive subjects the age-adjusted association was not diminished but lost statistical significance. HTLV-I seroprevalence may be independently associated with progression to severe neoplasia of the cervix.

Original languageEnglish (US)
Pages (from-to)23-26
Number of pages4
JournalInternational Journal of Cancer
Volume61
Issue number1
DOIs
StatePublished - 1995
Externally publishedYes

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Jamaica
Cervix Uteri
Viruses
T-Lymphocytes
Colposcopy
Papillomaviridae
Neoplasms
Papanicolaou Test
Human T-lymphotropic virus 1
Population Control
Seroepidemiologic Studies
Sexual Behavior
Japan
Pathology
Carcinoma
Biopsy
Polymerase Chain Reaction
DNA

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Strickler, H., Rattray, C., Escoffery, C., Manns, A., Schiffman, M. H., Brown, C., ... Blatiner, W. A. (1995). Human T-cell lymphotropic virus type I and severe neoplasia of the cervix in Jamaica. International Journal of Cancer, 61(1), 23-26. https://doi.org/10.1002/ijc.2910610105

Human T-cell lymphotropic virus type I and severe neoplasia of the cervix in Jamaica. / Strickler, Howard; Rattray, C.; Escoffery, C.; Manns, A.; Schiffman, M. H.; Brown, C.; Cranston, B.; Hanchard, B.; Palefsky, J. M.; Blatiner, W. A.

In: International Journal of Cancer, Vol. 61, No. 1, 1995, p. 23-26.

Research output: Contribution to journalArticle

Strickler, H, Rattray, C, Escoffery, C, Manns, A, Schiffman, MH, Brown, C, Cranston, B, Hanchard, B, Palefsky, JM & Blatiner, WA 1995, 'Human T-cell lymphotropic virus type I and severe neoplasia of the cervix in Jamaica', International Journal of Cancer, vol. 61, no. 1, pp. 23-26. https://doi.org/10.1002/ijc.2910610105
Strickler, Howard ; Rattray, C. ; Escoffery, C. ; Manns, A. ; Schiffman, M. H. ; Brown, C. ; Cranston, B. ; Hanchard, B. ; Palefsky, J. M. ; Blatiner, W. A. / Human T-cell lymphotropic virus type I and severe neoplasia of the cervix in Jamaica. In: International Journal of Cancer. 1995 ; Vol. 61, No. 1. pp. 23-26.
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