Gut-brain nutrient sensing in food reward

Ari Shechter, Gary J. Schwartz

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

For the past several decades, vagal and hormonal gut-brain negative feedback signaling mechanisms that promote satiety and subsequent suppression of food intake have been explored. In addition, a separate positive feedback process termed "appetition," involving postoral signaling from the gut to the brain, has been shown to promote food intake and produce flavor-nutrient preference conditioning. Afferent fibers emerging from the vagus nerve form the main pathway by which information is relayed from the abdominal viscera to the hindbrain and eventually other higher brain regions involved in food intake. Using a specialized subdiaphragmatic vagal deafferentation technique, it was observed that gut vagal and splanchnic afferents play a role in the negative feedback control of satiety after nutrient intake; however, these afferents are not required for nutrient reinforcement or flavor-nutrient preference conditioning, thereby highlighting the distinction between the processes of satiation and appetition. By linking these physiological and behavioral processes to a neurochemical mechanism, it was found that striatal dopamine release induced by intragastric glucose infusion is involved in sweet appetite conditioning. The mechanisms underlying appetition are still being investigated but may involve other nondopaminergic neurochemical systems and/or presently undiscovered hormonal mediators. Future work to delineate the biological mechanisms whereby appetition drives increased intake and conditioned food preference in response to ingestion should take a multifaceted approach by integrating hormonal, neurophysiological, and behavioral techniques.

Original languageEnglish (US)
JournalAppetite
DOIs
StateAccepted/In press - Aug 15 2016

Fingerprint

Reward
Eating
Food
Viscera
Brain
Physiological Phenomena
Satiation
Corpus Striatum
Food Preferences
Rhombencephalon
Vagus Nerve
Appetite
Dopamine
Glucose
Conditioning (Psychology)

Keywords

  • Appetite
  • Flavor conditioning
  • Food intake
  • Satiety
  • Sugar
  • Vagus nerve

ASJC Scopus subject areas

  • Psychology(all)
  • Nutrition and Dietetics

Cite this

Gut-brain nutrient sensing in food reward. / Shechter, Ari; Schwartz, Gary J.

In: Appetite, 15.08.2016.

Research output: Contribution to journalArticle

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