CSF-1 - A mononuclear phagocyte lineage-specific hemopoietic growth factor

E. R. Stanley, L. J. Guilbert, R. J. Tushinski, S. H. Bartelmez

Research output: Contribution to journalArticle

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Abstract

CSF-1 is the only mononuclear phagocyte lineage-specific growth factor described to date. Despite its unusually high degree of glycosylation, it appears that a completely deglycosylated form might still retain in vitro biological activity. This conclusion raises the question of the function of the CSF-1 oligosaccharides. Since CSF-1 acts on macrophages that release proteases and which are found with CSF-1 in areas of local inflammation, its substantial glycosylation may provide protection from extracellular degradation. It is interesting to note that without its carbohydrate, CSF-1 shares structure-activity relationships with the biologically active subunit of nerve growth factor (β-NGF). β-NGF is a dimer composed of two noncovalently associated polypeptide chains of M(r) ~ 14,000 with identical or completely overlapping sequences. Determination of the amino acid sequence of the CSF-1 polypeptide chain(s) will resolve the question of whether CSF-1 is related to β-NGF, which belongs to the family of insulin-related growth factors. As in the case of other growth factors and the polypeptide hormones, the biological effects of CSF-1 are mediated by a specific cell-surface receptor. These effects include the stimulation of target cell survival, proliferation, and differentiation as well as other morphological and functional changes. Studies on the mechanism(s) by which the CSF-1 receptor system leads to the pleiotropic effects of CSF-1 on mononuclear phagocytes will be facilitated by the recent development of methods for obtaining homogeneous populations of target cells (BMM). However, the restricted occurrence of the CSF-1 receptor among cells of the mononuclear phagocytic series makes it an excellent marker of this lineage, and has already led to the delineation of two new growth factors that may be involved in directing hemopoietic cell proliferation and differentiation at the level of the hemopoietic stem cell. These latter studies may help elucidate the basic mechanisms by which several growth factors interact in the generation of mature cells from immature precursor cells in proliferating tissues.

Original languageEnglish (US)
Pages (from-to)151-159
Number of pages9
JournalJournal of Cellular Biochemistry
Volume21
Issue number2
StatePublished - 1983

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Macrophage Colony-Stimulating Factor
Phagocytes
Intercellular Signaling Peptides and Proteins
Nerve Growth Factor
Macrophage Colony-Stimulating Factor Receptors
Glycosylation
Cell proliferation
Cell Differentiation
Cell Proliferation
Peptides
Peptide Hormones
Macrophages
Health Services Needs and Demand
Protein Sequence Analysis
Cell Surface Receptors
Structure-Activity Relationship
Bioactivity
Stem cells
Oligosaccharides
Dimers

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology

Cite this

Stanley, E. R., Guilbert, L. J., Tushinski, R. J., & Bartelmez, S. H. (1983). CSF-1 - A mononuclear phagocyte lineage-specific hemopoietic growth factor. Journal of Cellular Biochemistry, 21(2), 151-159.

CSF-1 - A mononuclear phagocyte lineage-specific hemopoietic growth factor. / Stanley, E. R.; Guilbert, L. J.; Tushinski, R. J.; Bartelmez, S. H.

In: Journal of Cellular Biochemistry, Vol. 21, No. 2, 1983, p. 151-159.

Research output: Contribution to journalArticle

Stanley, ER, Guilbert, LJ, Tushinski, RJ & Bartelmez, SH 1983, 'CSF-1 - A mononuclear phagocyte lineage-specific hemopoietic growth factor', Journal of Cellular Biochemistry, vol. 21, no. 2, pp. 151-159.
Stanley ER, Guilbert LJ, Tushinski RJ, Bartelmez SH. CSF-1 - A mononuclear phagocyte lineage-specific hemopoietic growth factor. Journal of Cellular Biochemistry. 1983;21(2):151-159.
Stanley, E. R. ; Guilbert, L. J. ; Tushinski, R. J. ; Bartelmez, S. H. / CSF-1 - A mononuclear phagocyte lineage-specific hemopoietic growth factor. In: Journal of Cellular Biochemistry. 1983 ; Vol. 21, No. 2. pp. 151-159.
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