Younger adults with acute myeloid leukemia in remission for ≥3 years have a high likelihood of cure: The ECOG experience in over 1200 patients

Justin M. Watts; Xin Victoria Wang; Mark R. Litzow; Selina M. Luger; Hillard M. Lazarus; Peter A. Cassileth; Hugo F. Fernandez; Dan Douer; Lynette Zickl; Elisabeth Paietta; Jacob M. Rowe; Martin S. Tallman

doi:10.1016/j.leukres.2014.05.018

Younger adults with acute myeloid leukemia in remission for ≥3 years have a high likelihood of cure: The ECOG experience in over 1200 patients

Justin M. Watts, Xin Victoria Wang, Mark R. Litzow, Selina M. Luger, Hillard M. Lazarus, Peter A. Cassileth, Hugo F. Fernandez, Dan Douer, Lynette Zickl, Elisabeth Paietta, Jacob M. Rowe, Martin S. Tallman

Oncology

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

We examined 1229 younger patients with acute myeloid leukemia who achieved CR1 on Eastern Cooperative Oncology Group trials. We defined late relapse as occurring after ≥3 years of CR1. With median follow-up of 11.3 years, there were 14 late relapses (1.1% of CR1 patients; 3.3% of 3-year CR1 patients). Eight achieved second CR and median overall survival after late relapse was 3.2 years. Most patients tested (9/11) had a normal karyotype at diagnosis; none had new cytogenetic abnormalities at relapse. Late relapse is rare and nearly all 3-year CR1 patients are cured. If late relapse occurs, outcomes are relatively favorable.

Original language	English (US)
Pages (from-to)	901-906
Number of pages	6
Journal	Leukemia Research
Volume	38
Issue number	8
DOIs	https://doi.org/10.1016/j.leukres.2014.05.018
State	Published - Aug 2014

Keywords

Acute myeloid leukemia
Clinical trials
Late relapse
Normal cytogenetics
Outcomes

ASJC Scopus subject areas

Hematology
Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.leukres.2014.05.018

Cite this

Watts, J. M., Wang, X. V., Litzow, M. R., Luger, S. M., Lazarus, H. M., Cassileth, P. A., Fernandez, H. F., Douer, D., Zickl, L., Paietta, E., Rowe, J. M., & Tallman, M. S. (2014). Younger adults with acute myeloid leukemia in remission for ≥3 years have a high likelihood of cure: The ECOG experience in over 1200 patients. Leukemia Research, 38(8), 901-906. https://doi.org/10.1016/j.leukres.2014.05.018

Watts, JM, Wang, XV, Litzow, MR, Luger, SM, Lazarus, HM, Cassileth, PA, Fernandez, HF, Douer, D, Zickl, L, Paietta, E, Rowe, JM & Tallman, MS 2014, 'Younger adults with acute myeloid leukemia in remission for ≥3 years have a high likelihood of cure: The ECOG experience in over 1200 patients', Leukemia Research, vol. 38, no. 8, pp. 901-906. https://doi.org/10.1016/j.leukres.2014.05.018

@article{b36540404b854598a47ffd910582bd83,

title = "Younger adults with acute myeloid leukemia in remission for ≥3 years have a high likelihood of cure: The ECOG experience in over 1200 patients",

abstract = "We examined 1229 younger patients with acute myeloid leukemia who achieved CR1 on Eastern Cooperative Oncology Group trials. We defined late relapse as occurring after ≥3 years of CR1. With median follow-up of 11.3 years, there were 14 late relapses (1.1% of CR1 patients; 3.3% of 3-year CR1 patients). Eight achieved second CR and median overall survival after late relapse was 3.2 years. Most patients tested (9/11) had a normal karyotype at diagnosis; none had new cytogenetic abnormalities at relapse. Late relapse is rare and nearly all 3-year CR1 patients are cured. If late relapse occurs, outcomes are relatively favorable.",

keywords = "Acute myeloid leukemia, Clinical trials, Late relapse, Normal cytogenetics, Outcomes",

author = "Watts, {Justin M.} and Wang, {Xin Victoria} and Litzow, {Mark R.} and Luger, {Selina M.} and Lazarus, {Hillard M.} and Cassileth, {Peter A.} and Fernandez, {Hugo F.} and Dan Douer and Lynette Zickl and Elisabeth Paietta and Rowe, {Jacob M.} and Tallman, {Martin S.}",

year = "2014",

month = aug,

doi = "10.1016/j.leukres.2014.05.018",

language = "English (US)",

volume = "38",

pages = "901--906",

journal = "Leukemia Research",

issn = "0145-2126",

publisher = "Elsevier Limited",

number = "8",

}

TY - JOUR

T1 - Younger adults with acute myeloid leukemia in remission for ≥3 years have a high likelihood of cure

T2 - The ECOG experience in over 1200 patients

AU - Watts, Justin M.

AU - Wang, Xin Victoria

AU - Litzow, Mark R.

AU - Luger, Selina M.

AU - Lazarus, Hillard M.

AU - Cassileth, Peter A.

AU - Fernandez, Hugo F.

AU - Douer, Dan

AU - Zickl, Lynette

AU - Paietta, Elisabeth

AU - Rowe, Jacob M.

AU - Tallman, Martin S.

PY - 2014/8

Y1 - 2014/8

N2 - We examined 1229 younger patients with acute myeloid leukemia who achieved CR1 on Eastern Cooperative Oncology Group trials. We defined late relapse as occurring after ≥3 years of CR1. With median follow-up of 11.3 years, there were 14 late relapses (1.1% of CR1 patients; 3.3% of 3-year CR1 patients). Eight achieved second CR and median overall survival after late relapse was 3.2 years. Most patients tested (9/11) had a normal karyotype at diagnosis; none had new cytogenetic abnormalities at relapse. Late relapse is rare and nearly all 3-year CR1 patients are cured. If late relapse occurs, outcomes are relatively favorable.

AB - We examined 1229 younger patients with acute myeloid leukemia who achieved CR1 on Eastern Cooperative Oncology Group trials. We defined late relapse as occurring after ≥3 years of CR1. With median follow-up of 11.3 years, there were 14 late relapses (1.1% of CR1 patients; 3.3% of 3-year CR1 patients). Eight achieved second CR and median overall survival after late relapse was 3.2 years. Most patients tested (9/11) had a normal karyotype at diagnosis; none had new cytogenetic abnormalities at relapse. Late relapse is rare and nearly all 3-year CR1 patients are cured. If late relapse occurs, outcomes are relatively favorable.

KW - Acute myeloid leukemia

KW - Clinical trials

KW - Late relapse

KW - Normal cytogenetics

KW - Outcomes

UR - http://www.scopus.com/inward/record.url?scp=84904577671&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84904577671&partnerID=8YFLogxK

U2 - 10.1016/j.leukres.2014.05.018

DO - 10.1016/j.leukres.2014.05.018

M3 - Article

C2 - 24986381

AN - SCOPUS:84904577671

SN - 0145-2126

VL - 38

SP - 901

EP - 906

JO - Leukemia Research

JF - Leukemia Research

IS - 8

ER -

Younger adults with acute myeloid leukemia in remission for ≥3 years have a high likelihood of cure: The ECOG experience in over 1200 patients

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this