Younger adults with acute myeloid leukemia in remission for ≥3 years have a high likelihood of cure: The ECOG experience in over 1200 patients

Justin M. Watts, Xin Victoria Wang, Mark R. Litzow, Selina M. Luger, Hillard M. Lazarus, Peter A. Cassileth, Hugo F. Fernandez, Dan Douer, Lynette Zickl, Elisabeth Paietta, Jacob M. Rowe, Martin S. Tallman

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

We examined 1229 younger patients with acute myeloid leukemia who achieved CR1 on Eastern Cooperative Oncology Group trials. We defined late relapse as occurring after ≥3 years of CR1. With median follow-up of 11.3 years, there were 14 late relapses (1.1% of CR1 patients; 3.3% of 3-year CR1 patients). Eight achieved second CR and median overall survival after late relapse was 3.2 years. Most patients tested (9/11) had a normal karyotype at diagnosis; none had new cytogenetic abnormalities at relapse. Late relapse is rare and nearly all 3-year CR1 patients are cured. If late relapse occurs, outcomes are relatively favorable.

Original languageEnglish (US)
Pages (from-to)901-906
Number of pages6
JournalLeukemia Research
Volume38
Issue number8
DOIs
StatePublished - Aug 2014

Keywords

  • Acute myeloid leukemia
  • Clinical trials
  • Late relapse
  • Normal cytogenetics
  • Outcomes

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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    Watts, J. M., Wang, X. V., Litzow, M. R., Luger, S. M., Lazarus, H. M., Cassileth, P. A., Fernandez, H. F., Douer, D., Zickl, L., Paietta, E., Rowe, J. M., & Tallman, M. S. (2014). Younger adults with acute myeloid leukemia in remission for ≥3 years have a high likelihood of cure: The ECOG experience in over 1200 patients. Leukemia Research, 38(8), 901-906. https://doi.org/10.1016/j.leukres.2014.05.018