Young woman with a four-year history of epilepsy and progressive focal cortical atrophy - What is the diagnosis?

S. Pati, M. I. Cobos-Sillero, B. Buchbinder, E. Eskandar, A. J. Cole

Research output: Contribution to journalArticle


The pathogenesis of disease progression in drug-refractory epilepsy is poorly understood. We report the case of a young woman with a four-year history of epilepsy that progressed rapidly as evidenced by the development of progressive focal cortical atrophy. She underwent biopsy that showed perinatal ischemia and a prominent inflammatory response, including T-cell infiltration and microglial activation. There was no consensus reached on the final diagnosis although the hypothesis of dual pathology (adult variant of Rasmussen's encephalitis and perinatal stroke) was considered. The possible role of inflammation in the progression of epilepsy caused by a "static" lesion (perinatal stroke) is discussed.

Original languageEnglish (US)
Pages (from-to)91-95
Number of pages5
JournalEpilepsy and Behavior Case Reports
Issue number1
StatePublished - Jan 1 2014
Externally publishedYes



  • Neuroinflammation
  • Perinatal stroke
  • Progressive epilepsy
  • Rasmussen's encephalitis

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Behavioral Neuroscience

Cite this