Yohimbine treatment of sexual side effects induced by serotonin reuptake blockers

Eric Hollander, A. McCarley

Research output: Contribution to journalArticle

92 Citations (Scopus)

Abstract

Background: Preclinical and clinical studies suggest that yohimbine facilitates sexual behavior and may be helpful in the treatment of male impotence. A single case report suggests that yohimbine may be used to treat the sexual side effects of clomipramine. This study evaluated yohimbine as a treatment for the sexual side effects caused by serotonin reuptake blockers. Method: Six patients with either obsessive compulsive disorder, trichotillomania, anxiety, or affective disorders who suffered sexual side effects after treatment with serotonin reuptake blockers were given yohimbine on a p.r.n. basis in an open clinical trial. Various doses of yohimbine were used to determine the ideal dose for each patient. Results: Five of the six patients experienced improved sexual functioning after taking yohimbine. One patient who failed to comply with yohimbine treatment had no therapeutic effects. Side effects of yohimbine included excessive sweating, increased anxiety, and a wound-up feeling in some patients. Conclusion: The results of this study indicate that yohimbine may be an effective treatment for the sexual side effects caused by serotonin reuptake blockers. Future controlled studies are needed to further investigate the effectiveness and safety of yohimbine for this indication.

Original languageEnglish (US)
Pages (from-to)207-209
Number of pages3
JournalJournal of Clinical Psychiatry
Volume53
Issue number6
StatePublished - 1992
Externally publishedYes

Fingerprint

Yohimbine
Serotonin
Therapeutics
Trichotillomania
Clomipramine
Sweating
Obsessive-Compulsive Disorder
Therapeutic Uses
Erectile Dysfunction
Anxiety Disorders
Mood Disorders
Sexual Behavior
Emotions
Anxiety
Clinical Trials
Safety

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Clinical Psychology

Cite this

Yohimbine treatment of sexual side effects induced by serotonin reuptake blockers. / Hollander, Eric; McCarley, A.

In: Journal of Clinical Psychiatry, Vol. 53, No. 6, 1992, p. 207-209.

Research output: Contribution to journalArticle

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