Yellow staining caused by 4,4'-methylenedianiline exposure. Occurrence among molded plastics workers

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Workers engaged in a molded plastics operation were studied to determine the etiology of yellow staining reactions involving the skin, nails, and hair. A walk-through survey of the facility, medical interviews, physical interviews, physical examinations, and blood and urine tests were performed. 4,4'-Methylenedianiline (MDA), a component chemical of the manufacturing process, produced intense yellow discoloration of nitrocellulose paper in the laboratory and appeared to volatilize readily under ambient conditions. Thirty-five (65%) of 54 process workers showed varying degrees of staining while 11 workers employed in other parts of the factory showed no staining. Yellow staining was restricted to areas of the body where direct contact with MDA appeared likely. Laboratory studies did not provide evidence of systemic toxic effect Because MDA is a known hepatotoxin for man, with carcinogenic properties in animal test systems, it is important to recognize yellow staining as a cutaneous marker of exposure to this chemical.

Original languageEnglish (US)
Pages (from-to)1022-1027
Number of pages6
JournalArchives of Dermatology
Volume121
Issue number8
DOIs
StatePublished - 1985
Externally publishedYes

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Plastics
Staining and Labeling
Chemical Phenomena
Interviews
Skin
Collodion
Poisons
Hematologic Tests
Nails
Hair
Physical Examination
4,4'-diaminodiphenylmethane
Urine

ASJC Scopus subject areas

  • Dermatology

Cite this

Yellow staining caused by 4,4'-methylenedianiline exposure. Occurrence among molded plastics workers. / Cohen, Steven R.

In: Archives of Dermatology, Vol. 121, No. 8, 1985, p. 1022-1027.

Research output: Contribution to journalArticle

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