WT1 expression at diagnosis does not predict survival in pediatric AML: A report from the children's oncology group

Suzie A. Noronha; Jason E. Farrar; Todd A. Alonzo; Robert B. Gerbing; Norman J. Lacayo; Gary V. Dahl; Yaddanapudi Ravindranath; Robert J. Arceci; David M. Loeb

doi:10.1002/pbc.22142

WT1 expression at diagnosis does not predict survival in pediatric AML: A report from the children's oncology group

Suzie A. Noronha, Jason E. Farrar, Todd A. Alonzo, Robert B. Gerbing, Norman J. Lacayo, Gary V. Dahl, Yaddanapudi Ravindranath, Robert J. Arceci, David M. Loeb

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

WT1 is a transcription factor that is aberrantly overexpressed in acute and chronic leukemias. Overexpression of WT1 in pediatric acute myeloid leukemia has been reported, but the prognostic significance is unclear because sample sizes in these studies have been relatively small. WT1 expression was measured by quantitative RT-PCR in samples obtained at diagnosis from 155 pediatric AML patients treated on a cooperative group protocol. Neither overall survival nor event-free survival was correlated with WT1 expression.

Original language	English (US)
Pages (from-to)	1136-1139
Number of pages	4
Journal	Pediatric Blood and Cancer
Volume	53
Issue number	6
DOIs	https://doi.org/10.1002/pbc.22142
State	Published - 2009
Externally published	Yes

Keywords

Acute myeloid leukemia
Prognosis
Prognostic factor
Wilms tumor 1

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Hematology
Oncology

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10.1002/pbc.22142

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title = "WT1 expression at diagnosis does not predict survival in pediatric AML: A report from the children's oncology group",

abstract = "WT1 is a transcription factor that is aberrantly overexpressed in acute and chronic leukemias. Overexpression of WT1 in pediatric acute myeloid leukemia has been reported, but the prognostic significance is unclear because sample sizes in these studies have been relatively small. WT1 expression was measured by quantitative RT-PCR in samples obtained at diagnosis from 155 pediatric AML patients treated on a cooperative group protocol. Neither overall survival nor event-free survival was correlated with WT1 expression.",

keywords = "Acute myeloid leukemia, Prognosis, Prognostic factor, Wilms tumor 1",

author = "Noronha, {Suzie A.} and Farrar, {Jason E.} and Alonzo, {Todd A.} and Gerbing, {Robert B.} and Lacayo, {Norman J.} and Dahl, {Gary V.} and Yaddanapudi Ravindranath and Arceci, {Robert J.} and Loeb, {David M.}",

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T1 - WT1 expression at diagnosis does not predict survival in pediatric AML

T2 - A report from the children's oncology group

AU - Noronha, Suzie A.

AU - Farrar, Jason E.

AU - Alonzo, Todd A.

AU - Gerbing, Robert B.

AU - Lacayo, Norman J.

AU - Dahl, Gary V.

AU - Ravindranath, Yaddanapudi

AU - Arceci, Robert J.

AU - Loeb, David M.

PY - 2009

Y1 - 2009

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AB - WT1 is a transcription factor that is aberrantly overexpressed in acute and chronic leukemias. Overexpression of WT1 in pediatric acute myeloid leukemia has been reported, but the prognostic significance is unclear because sample sizes in these studies have been relatively small. WT1 expression was measured by quantitative RT-PCR in samples obtained at diagnosis from 155 pediatric AML patients treated on a cooperative group protocol. Neither overall survival nor event-free survival was correlated with WT1 expression.

KW - Acute myeloid leukemia

KW - Prognosis

KW - Prognostic factor

KW - Wilms tumor 1

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WT1 expression at diagnosis does not predict survival in pediatric AML: A report from the children's oncology group

Abstract

Keywords

ASJC Scopus subject areas

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