TY - JOUR
T1 - Would selenium supplementation aid in therapy for Chagas Disease?
AU - Jelicks, Linda A.
AU - de Souza, Andréa P.
AU - Araújo-Jorge, Tania C.
AU - Tanowitz, Herbert B.
N1 - Funding Information:
This work was supported in part by grants from the United States National Institute of Health grants CA123334 and AI062730 (LAJ) and AI076248 (HBT), Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Coordenação de Aperfeiçoamento de Pessoal de Ensino Superior (CAPES), FIOCRUZ, and FAPERJ. All animal studies were performed in accordance with the guidelines established by the Institutional Animal Care and Use Committee of the Albert Einstein College of Medicine.
PY - 2011/3
Y1 - 2011/3
N2 - Chagas disease, a neglected tropical disease discovered over 100 years ago, is caused by the intracellular parasite Trypanosoma cruzi and is most frequently associated with chronic cardiomyopathy and digestive disorders. Initial invasion of cells is followed by progressive inflammatory destruction of heart, muscles, nerves, and gastrointestinal (GI) tract tissue. Approximately 30% of patients progress to a chronic cardiomyopathy associated with increased morbidity and mortality. Seven to 10% of patients develop megasyndromes involving the GI tract, in particular, the esophagus and the colon. Results from several studies suggest that selenium (Se) deficiency could be an important factor in the pathogenesis of Chagas disease. In this opinion article, Se supplementation is proposed as an adjuvant therapy for treatment of chronic Chagas disease.
AB - Chagas disease, a neglected tropical disease discovered over 100 years ago, is caused by the intracellular parasite Trypanosoma cruzi and is most frequently associated with chronic cardiomyopathy and digestive disorders. Initial invasion of cells is followed by progressive inflammatory destruction of heart, muscles, nerves, and gastrointestinal (GI) tract tissue. Approximately 30% of patients progress to a chronic cardiomyopathy associated with increased morbidity and mortality. Seven to 10% of patients develop megasyndromes involving the GI tract, in particular, the esophagus and the colon. Results from several studies suggest that selenium (Se) deficiency could be an important factor in the pathogenesis of Chagas disease. In this opinion article, Se supplementation is proposed as an adjuvant therapy for treatment of chronic Chagas disease.
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U2 - 10.1016/j.pt.2010.12.002
DO - 10.1016/j.pt.2010.12.002
M3 - Review article
C2 - 21212020
AN - SCOPUS:79952103084
SN - 1471-4922
VL - 27
SP - 102
EP - 105
JO - Trends in Parasitology
JF - Trends in Parasitology
IS - 3
ER -