Would selenium supplementation aid in therapy for Chagas Disease?

Linda A. Jelicks, Andréa P. de Souza, Tania C. Araújo-Jorge, Herbert B. Tanowitz

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Chagas disease, a neglected tropical disease discovered over 100 years ago, is caused by the intracellular parasite Trypanosoma cruzi and is most frequently associated with chronic cardiomyopathy and digestive disorders. Initial invasion of cells is followed by progressive inflammatory destruction of heart, muscles, nerves, and gastrointestinal (GI) tract tissue. Approximately 30% of patients progress to a chronic cardiomyopathy associated with increased morbidity and mortality. Seven to 10% of patients develop megasyndromes involving the GI tract, in particular, the esophagus and the colon. Results from several studies suggest that selenium (Se) deficiency could be an important factor in the pathogenesis of Chagas disease. In this opinion article, Se supplementation is proposed as an adjuvant therapy for treatment of chronic Chagas disease.

Original languageEnglish (US)
Pages (from-to)102-105
Number of pages4
JournalTrends in Parasitology
Volume27
Issue number3
DOIs
StatePublished - Mar 2011

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Chagas Disease
Selenium
Cardiomyopathies
Gastrointestinal Tract
Neglected Diseases
Trypanosoma cruzi
Esophagus
Myocardium
Colon
Parasites
Chronic Disease
Therapeutics
Morbidity
Mortality

ASJC Scopus subject areas

  • Infectious Diseases
  • Parasitology

Cite this

Jelicks, L. A., de Souza, A. P., Araújo-Jorge, T. C., & Tanowitz, H. B. (2011). Would selenium supplementation aid in therapy for Chagas Disease? Trends in Parasitology, 27(3), 102-105. https://doi.org/10.1016/j.pt.2010.12.002

Would selenium supplementation aid in therapy for Chagas Disease? / Jelicks, Linda A.; de Souza, Andréa P.; Araújo-Jorge, Tania C.; Tanowitz, Herbert B.

In: Trends in Parasitology, Vol. 27, No. 3, 03.2011, p. 102-105.

Research output: Contribution to journalArticle

Jelicks, LA, de Souza, AP, Araújo-Jorge, TC & Tanowitz, HB 2011, 'Would selenium supplementation aid in therapy for Chagas Disease?', Trends in Parasitology, vol. 27, no. 3, pp. 102-105. https://doi.org/10.1016/j.pt.2010.12.002
Jelicks, Linda A. ; de Souza, Andréa P. ; Araújo-Jorge, Tania C. ; Tanowitz, Herbert B. / Would selenium supplementation aid in therapy for Chagas Disease?. In: Trends in Parasitology. 2011 ; Vol. 27, No. 3. pp. 102-105.
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