Worsening of contact dermatitis by oral hydroxyzine: A case report

Research output: Contribution to journalArticle

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Abstract

Hydroxyzine is commonly used to treat pruritic skin lesions. Although rare, hydroxyzine can sometimes be linked to worsening dermatitis in patients who have sensitivities to phenothiazines and/or ethylenediamines. Herein we describe a patient who developed papulovesicular eruptions following the use of topical neomycin. Our patient's contact dermatitis initially improved after the use of oral steroids. However, the patient's skin condition was exacerbated by the continued use of hydroxyzine to treat her pruritus. Patch testing was positive at 48 hours for neomycin sulfate, ethylenediamine dihydrochloride, and p-phenylenediamine. Given the suspected cross-reactivity between hydroxyzine and ethylenediamine, hydroxyzine was discontinued and the patient's cutaneous symptoms improved. In summary, physicians must be aware that oral hydroxyzine can worsen contact dermatitis in ethylenediamine-sensitive patients.

Original languageEnglish (US)
JournalDermatology Online Journal
Volume19
Issue number2
StatePublished - Feb 2013

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Hydroxyzine
ethylenediamine
Contact Dermatitis
Neomycin
Skin
Ethylenediamines
Phenothiazines
Dermatitis
Pruritus
Steroids
Physicians

ASJC Scopus subject areas

  • Dermatology

Cite this

Worsening of contact dermatitis by oral hydroxyzine : A case report. / Reid, Nianda; Jariwala, Sunit P.; Jerschow, Elina; Hudes, Golda; Rosenstreich, David L.; Fodeman, Jason.

In: Dermatology Online Journal, Vol. 19, No. 2, 02.2013.

Research output: Contribution to journalArticle

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