Wnt signaling in osteosarcoma

Amit Singla, Jichuan Wang, Rui Yang, David S. Geller, David M. Loeb, Bang H. Hoang

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Wnt molecules are a class of cysteine-rich secreted glycoproteins that participate in various developmental events during embryogenesis and adult tissue homeostasis. Since its discovery in 1982, the roles of Wnt signaling have been established in various key regulatory systems in biology. Wnt signals exert pleiotropic effects, including mitogenic stimulation, cell fate specification, and differentiation. The Wnt signaling pathway in humans has been shown to be involved in a wide variety of disorders including colon cancer, sarcoma, coronary artery disease, tetra-amelia, Mullerian duct regression, eye vascular defects, and abnormal bone mass. The canonical Wnt pathway functions by regulating the function of the transcriptional coactivator β-catenin, whereas noncanonical pathways function independent of β-catenin. Although the role of Wnt signaling is well established in epithelial malignancies, its role in mesenchymal tumors is more controversial. Some studies have suggested that Wnt signaling plays a pro-oncogenic role in various sarcomas by driving cell proliferation and motility; however, others have reported that Wnt signaling acts as a tumor suppressor by committing tumor cells to differentiate into a mature lineage. Wnt signaling pathway also plays an important role in regulating cancer stem cell function. In this review, we will discuss Wnt signaling pathway and its role in osteosarcoma.

Original languageEnglish (US)
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer
Pages125-139
Number of pages15
DOIs
StatePublished - 2020

Publication series

NameAdvances in Experimental Medicine and Biology
Volume1258
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

Keywords

  • Cancer stem cell
  • Dickkopf
  • Frizzled- related protein
  • Osteosarcoma
  • Wnt
  • Wnt inhibitory protein
  • β-Catenin

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Singla, A., Wang, J., Yang, R., Geller, D. S., Loeb, D. M., & Hoang, B. H. (2020). Wnt signaling in osteosarcoma. In Advances in Experimental Medicine and Biology (pp. 125-139). (Advances in Experimental Medicine and Biology; Vol. 1258). Springer. https://doi.org/10.1007/978-3-030-43085-6_8