Willingness to Participate in Longitudinal Research among People with Chronic Pain Who Take Medical Cannabis

A Cross-Sectional Survey

Research output: Contribution to journalReview article

Abstract

Background: Regulatory barriers limit clinical trials of medical cannabis in the United States. Longitudinal cohort studies may be one feasible alternative that could yield clinically relevant information. Willingness to participate in such studies is not known. Materials and Methods: In October 2016, we surveyed a convenience sample of patients with chronic pain from two New York registered organizations (responsible for growing, processing, distributing, and retailing medical cannabis products). After a vignette describing a longitudinal cohort study involving weekly patient-reported outcomes and quarterly assessments of physical functioning and urine and blood tests, we asked about respondents' willingness to participate. We examined willingness to participate, duration of participation, and frequency of data collections overall and by subgroups, using multivariable logistic regression models. Results: Of 405 respondents (estimated response rate: 30%), 54% were women and 81% were white non-Hispanic. Neuropathy was the most common pain condition (67%) followed by inflammatory bowel disease (19%). Of respondents, 94% (95% CI 92-97%) thought that the study should be done, 85% (95% CI 81-88%) would definitely or probably enroll if asked, 76% (95% CI 72-81%) would participate for ≥1 year, and 59% (95% CI 54-64%) would respond to questions at least daily. Older age was the only factor associated with lower willingness to participate, lower willingness to participate for ≥1 year, and lower willingness to respond to questions at least daily. Conclusions: Nearly all respondents were supportive of the proposed study and most reported that they would enroll if asked. Enhanced engagement with older individuals may be needed to promote equal enrollment. Recruitment for longitudinal cohort studies with frequent data collection appears feasible in this patient population.

Original languageEnglish (US)
Pages (from-to)45-53
Number of pages9
JournalCannabis and Cannabinoid Research
Volume3
Issue number1
DOIs
StatePublished - Mar 1 2018

Fingerprint

Medical Marijuana
Chronic Pain
Cross-Sectional Studies
Longitudinal Studies
Cohort Studies
Research
Logistic Models
Hematologic Tests
Outcome Assessment (Health Care)
Clinical Trials
Urine
Organizations
Pain
Surveys and Questionnaires
Population

Keywords

  • analgesics
  • chronic pain
  • cohort studies
  • marijuana
  • medical marijuana

ASJC Scopus subject areas

  • Complementary and alternative medicine
  • Pharmacology (medical)
  • Pharmacology

Cite this

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title = "Willingness to Participate in Longitudinal Research among People with Chronic Pain Who Take Medical Cannabis: A Cross-Sectional Survey",
abstract = "Background: Regulatory barriers limit clinical trials of medical cannabis in the United States. Longitudinal cohort studies may be one feasible alternative that could yield clinically relevant information. Willingness to participate in such studies is not known. Materials and Methods: In October 2016, we surveyed a convenience sample of patients with chronic pain from two New York registered organizations (responsible for growing, processing, distributing, and retailing medical cannabis products). After a vignette describing a longitudinal cohort study involving weekly patient-reported outcomes and quarterly assessments of physical functioning and urine and blood tests, we asked about respondents' willingness to participate. We examined willingness to participate, duration of participation, and frequency of data collections overall and by subgroups, using multivariable logistic regression models. Results: Of 405 respondents (estimated response rate: 30{\%}), 54{\%} were women and 81{\%} were white non-Hispanic. Neuropathy was the most common pain condition (67{\%}) followed by inflammatory bowel disease (19{\%}). Of respondents, 94{\%} (95{\%} CI 92-97{\%}) thought that the study should be done, 85{\%} (95{\%} CI 81-88{\%}) would definitely or probably enroll if asked, 76{\%} (95{\%} CI 72-81{\%}) would participate for ≥1 year, and 59{\%} (95{\%} CI 54-64{\%}) would respond to questions at least daily. Older age was the only factor associated with lower willingness to participate, lower willingness to participate for ≥1 year, and lower willingness to respond to questions at least daily. Conclusions: Nearly all respondents were supportive of the proposed study and most reported that they would enroll if asked. Enhanced engagement with older individuals may be needed to promote equal enrollment. Recruitment for longitudinal cohort studies with frequent data collection appears feasible in this patient population.",
keywords = "analgesics, chronic pain, cohort studies, marijuana, medical marijuana",
author = "Bachhuber, {Marcus A.} and Arnsten, {Julia H.} and Starrels, {Joanna L.} and Cunningham, {Chinazo O.}",
year = "2018",
month = "3",
day = "1",
doi = "10.1089/can.2017.0051",
language = "English (US)",
volume = "3",
pages = "45--53",
journal = "Cannabis and Cannabinoid Research",
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TY - JOUR

T1 - Willingness to Participate in Longitudinal Research among People with Chronic Pain Who Take Medical Cannabis

T2 - A Cross-Sectional Survey

AU - Bachhuber, Marcus A.

AU - Arnsten, Julia H.

AU - Starrels, Joanna L.

AU - Cunningham, Chinazo O.

PY - 2018/3/1

Y1 - 2018/3/1

N2 - Background: Regulatory barriers limit clinical trials of medical cannabis in the United States. Longitudinal cohort studies may be one feasible alternative that could yield clinically relevant information. Willingness to participate in such studies is not known. Materials and Methods: In October 2016, we surveyed a convenience sample of patients with chronic pain from two New York registered organizations (responsible for growing, processing, distributing, and retailing medical cannabis products). After a vignette describing a longitudinal cohort study involving weekly patient-reported outcomes and quarterly assessments of physical functioning and urine and blood tests, we asked about respondents' willingness to participate. We examined willingness to participate, duration of participation, and frequency of data collections overall and by subgroups, using multivariable logistic regression models. Results: Of 405 respondents (estimated response rate: 30%), 54% were women and 81% were white non-Hispanic. Neuropathy was the most common pain condition (67%) followed by inflammatory bowel disease (19%). Of respondents, 94% (95% CI 92-97%) thought that the study should be done, 85% (95% CI 81-88%) would definitely or probably enroll if asked, 76% (95% CI 72-81%) would participate for ≥1 year, and 59% (95% CI 54-64%) would respond to questions at least daily. Older age was the only factor associated with lower willingness to participate, lower willingness to participate for ≥1 year, and lower willingness to respond to questions at least daily. Conclusions: Nearly all respondents were supportive of the proposed study and most reported that they would enroll if asked. Enhanced engagement with older individuals may be needed to promote equal enrollment. Recruitment for longitudinal cohort studies with frequent data collection appears feasible in this patient population.

AB - Background: Regulatory barriers limit clinical trials of medical cannabis in the United States. Longitudinal cohort studies may be one feasible alternative that could yield clinically relevant information. Willingness to participate in such studies is not known. Materials and Methods: In October 2016, we surveyed a convenience sample of patients with chronic pain from two New York registered organizations (responsible for growing, processing, distributing, and retailing medical cannabis products). After a vignette describing a longitudinal cohort study involving weekly patient-reported outcomes and quarterly assessments of physical functioning and urine and blood tests, we asked about respondents' willingness to participate. We examined willingness to participate, duration of participation, and frequency of data collections overall and by subgroups, using multivariable logistic regression models. Results: Of 405 respondents (estimated response rate: 30%), 54% were women and 81% were white non-Hispanic. Neuropathy was the most common pain condition (67%) followed by inflammatory bowel disease (19%). Of respondents, 94% (95% CI 92-97%) thought that the study should be done, 85% (95% CI 81-88%) would definitely or probably enroll if asked, 76% (95% CI 72-81%) would participate for ≥1 year, and 59% (95% CI 54-64%) would respond to questions at least daily. Older age was the only factor associated with lower willingness to participate, lower willingness to participate for ≥1 year, and lower willingness to respond to questions at least daily. Conclusions: Nearly all respondents were supportive of the proposed study and most reported that they would enroll if asked. Enhanced engagement with older individuals may be needed to promote equal enrollment. Recruitment for longitudinal cohort studies with frequent data collection appears feasible in this patient population.

KW - analgesics

KW - chronic pain

KW - cohort studies

KW - marijuana

KW - medical marijuana

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U2 - 10.1089/can.2017.0051

DO - 10.1089/can.2017.0051

M3 - Review article

VL - 3

SP - 45

EP - 53

JO - Cannabis and Cannabinoid Research

JF - Cannabis and Cannabinoid Research

SN - 2378-8763

IS - 1

ER -