Will the new cytogenetics replace the old cytogenetics?

M. Salman, S. C. Jhanwar, Harry Ostrer

Research output: Contribution to journalShort survey

36 Scopus citations

Abstract

With the advent of array-based comparative genomic hybridization technology, the analog cytogenetic analysis that has been used for the past 100 years could be replaced by the quantitative, microarray-based molecular analysis. Major advantages of the new array-based cytogenetic technologies are the high resolution and the high throughput. This technology is the first to offer an autonomous whole-chromosome analysis in one hybridization reaction for the detection of submicroscopic gains/losses. However, as with any new technology, it needs to be validated with regard to its performance in various applications (e.g. clinical genetic testing and cancer applications), comparative cost, and the data interpretation.

Original languageEnglish (US)
Pages (from-to)265-275
Number of pages11
JournalClinical Genetics
Volume66
Issue number4
DOIs
StatePublished - Oct 2004
Externally publishedYes

Keywords

  • Comparative genomic hybridization
  • Cytogenetics
  • Genetic screening
  • Genome
  • Microarray
  • Single nucleotide polymorphism

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

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