Will atherosclerosis limit clinical xenografting?

K. Reemtsma, R. N. Pierson, C. C. Marboe, R. E. Michler, C. R. Smith, E. A. Rose, J. J. Fenoglio

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Lesions typical of early atherosclerosis occurred in the chimpanzee-to-human renal graft in the absence of clinically apparent rejection or hypertension. Similar early lesions are identified in cardiac grafts from our primate xenograft model. It seems clear that atherosclerosis will eventually present a significant problem in cross-species transplantation. We speculate that identification of the pathogenic mechanism of this lesion and of the xenogeneic immune response may converge on humoral vascular injury and that the latter may eventually prove the rate-limiting factor in xenotransplantation.

Original languageEnglish (US)
Pages (from-to)108-118
Number of pages11
JournalTransplantation Proceedings
Volume19
Issue number4 SUPPL. 5
StatePublished - Dec 9 1987
Externally publishedYes

ASJC Scopus subject areas

  • Surgery
  • Transplantation

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  • Cite this

    Reemtsma, K., Pierson, R. N., Marboe, C. C., Michler, R. E., Smith, C. R., Rose, E. A., & Fenoglio, J. J. (1987). Will atherosclerosis limit clinical xenografting? Transplantation Proceedings, 19(4 SUPPL. 5), 108-118.