Will atherosclerosis limit clinical xenografting?

K. Reemtsma, R. N. Pierson, C. C. Marboe, Robert E. Michler, C. R. Smith, E. A. Rose, J. J. Fenoglio

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Lesions typical of early atherosclerosis occurred in the chimpanzee-to-human renal graft in the absence of clinically apparent rejection or hypertension. Similar early lesions are identified in cardiac grafts from our primate xenograft model. It seems clear that atherosclerosis will eventually present a significant problem in cross-species transplantation. We speculate that identification of the pathogenic mechanism of this lesion and of the xenogeneic immune response may converge on humoral vascular injury and that the latter may eventually prove the rate-limiting factor in xenotransplantation.

Original languageEnglish (US)
Pages (from-to)108-118
Number of pages11
JournalTransplantation Proceedings
Volume19
Issue number4 SUPPL. 5
StatePublished - 1987
Externally publishedYes

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Heterologous Transplantation
Atherosclerosis
Transplants
Pan troglodytes
Vascular System Injuries
Heterografts
Primates
Transplantation
Hypertension
Kidney

ASJC Scopus subject areas

  • Surgery
  • Transplantation

Cite this

Reemtsma, K., Pierson, R. N., Marboe, C. C., Michler, R. E., Smith, C. R., Rose, E. A., & Fenoglio, J. J. (1987). Will atherosclerosis limit clinical xenografting? Transplantation Proceedings, 19(4 SUPPL. 5), 108-118.

Will atherosclerosis limit clinical xenografting? / Reemtsma, K.; Pierson, R. N.; Marboe, C. C.; Michler, Robert E.; Smith, C. R.; Rose, E. A.; Fenoglio, J. J.

In: Transplantation Proceedings, Vol. 19, No. 4 SUPPL. 5, 1987, p. 108-118.

Research output: Contribution to journalArticle

Reemtsma, K, Pierson, RN, Marboe, CC, Michler, RE, Smith, CR, Rose, EA & Fenoglio, JJ 1987, 'Will atherosclerosis limit clinical xenografting?', Transplantation Proceedings, vol. 19, no. 4 SUPPL. 5, pp. 108-118.
Reemtsma K, Pierson RN, Marboe CC, Michler RE, Smith CR, Rose EA et al. Will atherosclerosis limit clinical xenografting? Transplantation Proceedings. 1987;19(4 SUPPL. 5):108-118.
Reemtsma, K. ; Pierson, R. N. ; Marboe, C. C. ; Michler, Robert E. ; Smith, C. R. ; Rose, E. A. ; Fenoglio, J. J. / Will atherosclerosis limit clinical xenografting?. In: Transplantation Proceedings. 1987 ; Vol. 19, No. 4 SUPPL. 5. pp. 108-118.
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