Abstract
Lesions typical of early atherosclerosis occurred in the chimpanzee-to-human renal graft in the absence of clinically apparent rejection or hypertension. Similar early lesions are identified in cardiac grafts from our primate xenograft model. It seems clear that atherosclerosis will eventually present a significant problem in cross-species transplantation. We speculate that identification of the pathogenic mechanism of this lesion and of the xenogeneic immune response may converge on humoral vascular injury and that the latter may eventually prove the rate-limiting factor in xenotransplantation.
Original language | English (US) |
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Pages (from-to) | 108-118 |
Number of pages | 11 |
Journal | Transplantation proceedings |
Volume | 19 |
Issue number | 4 SUPPL. 5 |
State | Published - 1987 |
Externally published | Yes |
ASJC Scopus subject areas
- Surgery
- Transplantation