Why antibodies disobey the hippocratic oath and end up doing harm

A new clue

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The appearance of methicillin-resistant Staphylococcus aureus (MRSA) as an endemic microbe, first in hospital and health care settings and more recently in the community, has led to a disastrous situation in which use of the available antibiotic armamentarium is increasingly ineffective and spawns further antibiotic resistance. This vicious cycle highlights the pressing need for an S. aureus vaccine. However, to date, clinical trials with S. aureus vaccines have not demonstrated sustained efficacy. In this issue of the JCI, Skurnik and colleagues report that specific antibodies to two different S. aureus surface polysaccharides, which independently promote effector cell killing of S. aureus in vitro and protection against S. aureus in animal models, bind to and abrogate the activity of one another when they are combined. This fascinating finding suggests a new paradigm to explain the failure of antibody immunity to S. aureus.

Original languageEnglish (US)
Pages (from-to)3099-3102
Number of pages4
JournalJournal of Clinical Investigation
Volume120
Issue number9
DOIs
StatePublished - Sep 1 2010

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Hippocratic Oath
Staphylococcus aureus
Antibodies
Vaccines
Methicillin-Resistant Staphylococcus aureus
Microbial Drug Resistance
Polysaccharides
Immunity
Animal Models
Clinical Trials
Anti-Bacterial Agents
Delivery of Health Care

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Why antibodies disobey the hippocratic oath and end up doing harm : A new clue. / Pirofski, Liise-anne.

In: Journal of Clinical Investigation, Vol. 120, No. 9, 01.09.2010, p. 3099-3102.

Research output: Contribution to journalArticle

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