White matter injury in infants with intraventricular haemorrhage: mechanisms and therapies

Praveen Ballabh, Linda S. de Vries

Research output: Contribution to journalReview articlepeer-review

5 Scopus citations

Abstract

Intraventricular haemorrhage (IVH) continues to be a major complication of prematurity that can result in cerebral palsy and cognitive impairment in survivors. No optimal therapy exists to prevent IVH or to treat its consequences. IVH varies in severity and can present as a bleed confined to the germinal matrix, small-to-large IVH or periventricular haemorrhagic infarction. Moderate-to-severe haemorrhage dilates the ventricle and damages the periventricular white matter. This white matter injury results from a constellation of blood-induced pathological reactions, including oxidative stress, glutamate excitotoxicity, inflammation, perturbed signalling pathways and remodelling of the extracellular matrix. Potential therapies for IVH are currently undergoing investigation in preclinical models and evidence from clinical trials suggests that stem cell treatment and/or endoscopic removal of clots from the cerebral ventricles could transform the outcome of infants with IVH. This Review presents an integrated view of new insights into the mechanisms underlying white matter injury in premature infants with IVH and highlights the importance of early detection of disability and immediate intervention in optimizing the outcomes of IVH survivors.

Original languageEnglish (US)
Pages (from-to)199-214
Number of pages16
JournalNature Reviews Neurology
Volume17
Issue number4
DOIs
StatePublished - Apr 2021

ASJC Scopus subject areas

  • Clinical Neurology
  • Cellular and Molecular Neuroscience

Fingerprint

Dive into the research topics of 'White matter injury in infants with intraventricular haemorrhage: mechanisms and therapies'. Together they form a unique fingerprint.

Cite this