TY - JOUR
T1 - What's good for the host is good for the bug
AU - Flynn, Jo Anne L.
AU - Chan, John
N1 - Funding Information:
We are indebted to Peter Small and Kathy DeRiemer for helpful discussion. We are grateful to David Russell, Elizabeth Rhoades, Michael Glickman, Steven Porcelli and Clifton Barry for providing data and information before publication. JoAnne L. Flynn is supported by the NIH (AI37859, AI47485, AI50732, HL71241, HL68526 and HL75845) and the American Lung Association (CI-016). John Chan is supported by the NIH (AI50732, HL71241 and HL68526).
PY - 2005/3
Y1 - 2005/3
N2 - Tuberculosis, caused by Mycobacterium tuberculosis, kills approximately two million people each year. The infection is characterized by an inflammatory response culminating in the formation of a granuloma, a collection of immune cells that controls the infection. However, the granuloma can be the source of immunopathology that encourages transmission. Recent data support the idea that mycobacterial products can positively and negatively regulate the inflammatory response. Our contention is that induction of the immune response and subsequent granuloma formation is beneficial to the host for control of infection, and is also beneficial to the bacillus, as a place to hide and as a means for transmitting the infection to naïve hosts.
AB - Tuberculosis, caused by Mycobacterium tuberculosis, kills approximately two million people each year. The infection is characterized by an inflammatory response culminating in the formation of a granuloma, a collection of immune cells that controls the infection. However, the granuloma can be the source of immunopathology that encourages transmission. Recent data support the idea that mycobacterial products can positively and negatively regulate the inflammatory response. Our contention is that induction of the immune response and subsequent granuloma formation is beneficial to the host for control of infection, and is also beneficial to the bacillus, as a place to hide and as a means for transmitting the infection to naïve hosts.
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U2 - 10.1016/j.tim.2005.01.005
DO - 10.1016/j.tim.2005.01.005
M3 - Article
C2 - 15737727
AN - SCOPUS:14644408757
SN - 0966-842X
VL - 13
SP - 98
EP - 102
JO - Trends in Microbiology
JF - Trends in Microbiology
IS - 3
ER -
