What Do Models Model? What Needs to Be Modeled?

Aristea S. Galanopoulou, Asla Pitkänen, Paul S. Buckmaster, Solomon L. Moshé

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

The main purpose of creating or identifying animal models for human seizures and epilepsies, as well as their associated pathologies and comorbidities, is to utilize them to elucidate the mechanisms underlying pathogenesis, and develop treatments that will likely translate into effective therapies. It is certainly not expected that models will be perfect, and bear identical features to human syndromes or diseases.It is therefore important to recognize the advantages and limitations of each animal model, and to recognize which human seizures/epilepsies/pathologies each model is most relevant to. It is also important to develop strategies to improve our ability to translate such animal model findings into the clinical arena, such as the development of biomarkers.In this chapter, we attempt to reclassify the animal models discussed in this book as models of seizures, epilepsy syndromes and etiology relevant models of epilepsies.

Original languageEnglish (US)
Title of host publicationModels of Seizures and Epilepsy
Subtitle of host publicationSecond Edition
PublisherElsevier Inc.
Pages1107-1119
Number of pages13
ISBN (Print)9780128040669
DOIs
StatePublished - Jan 1 2017

Keywords

  • Animal models
  • Epilepsy models
  • Etiology relevant models
  • Models of epilepsy syndromes
  • Seizure models

ASJC Scopus subject areas

  • Neuroscience(all)

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  • Cite this

    Galanopoulou, A. S., Pitkänen, A., Buckmaster, P. S., & Moshé, S. L. (2017). What Do Models Model? What Needs to Be Modeled? In Models of Seizures and Epilepsy: Second Edition (pp. 1107-1119). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-804066-9.00077-8