What can structure tell us about in vivo function? The case of aminoglycoside-resistance genes

M. Vetting, S. L. Roderick, S. Hegde, S. Magnet, J. S. Blanchard

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Resistance to antibiotics used in the treatment of bacterial infections is an expanding clinical problem. Aminoglycosides, one of the oldest classes of natural product antibiotics, exert their bactericidal effect as the result of inhibiting bacterial protein synthesis by binding to the acceptor site of the 30 S ribosomal subunit. The most common mechanism of clinical resistance to aminoglycosides results from the expression of enzymes that covalently modify the aminoglycoside. We will discuss the enzymology and structure of two representative chromosomally encoded aminoglycoside N-acetyltransferases, Mycabacterium tuberculasis AAC(2′)-lc and Salmanella enterica AAC(6′)-ly, and speculate about their possible physiological function and substrates.

Original languageEnglish (US)
Pages (from-to)520-522
Number of pages3
JournalBiochemical Society transactions
Volume31
Issue number3
DOIs
Publication statusPublished - Jun 1 2003

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Keywords

  • Acetyltransferase
  • Aminoglycoside
  • Antibiotic resistance
  • Mycobacterium tuberculosis
  • Salmonella enterica

ASJC Scopus subject areas

  • Biochemistry

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