Weight loss and breast cancer incidence in postmenopausal women

Rowan T. Chlebowski, Juhua Luo, Garnet L. Anderson, Wendy Barrington, Kerryn Reding, Michael S. Simon, Jo Ann E. Manson, Thomas E. Rohan, Jean Wactawski-Wende, Dorothy Lane, Howard Strickler, Yasmin Mosaver-Rahmani, Jo L. Freudenheim, Nazmus Saquib, Marcia L. Stefanick

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: Although obesity is an established risk factor for postmenopausal breast cancer, the results of weight loss and breast cancer studies are inconsistent. Therefore, we evaluated associations between weight change and breast cancer risk in postmenopausal women in the Women’s Health Initiative Observational Study. Methods: Postmenopausal women (n = 61,335) who had no prior breast cancer and a normal mammogram had body weight and height measured and body mass index (BMI) calculated at baseline and year 3. Weight change at year 3 was categorized as stable (<5%), loss (≥5%), or gain (≥5%) with further assessment of weight loss intentionality by self-report. Multivariable Cox proportional hazard regression models were used to evaluate relationships between weight change and subsequent breast cancer incidence. Results: During a mean follow-up of 11.4 years with 3061 incident breast cancers, women with weight loss (n = 8175) had a significantly lower risk of breast cancer compared with women whose weight remained stable (n = 41,139) (hazard ratio [HR], 0.88; 95% confidence interval [CI], 0.78-0.98; P =.02) with no interaction by BMI. Adjustment for mammography did not alter findings (HR, 0.88; 95% CI, 0.78-0.99) with no significant difference by weight loss intentionality. Weight gain (≥5%) (n = 12,021) was not associated with breast cancer risk (HR, 1.02; 95% CI, 0.93-1.11) but was associated with higher triple-negative breast cancer incidence (HR, 1.54; 95% CI, 1.16-2.05). Conclusions: Postmenopausal women who lose weight have lower breast cancer risk than those with stable weight. These findings suggest that postmenopausal women who lose weight may reduce their breast cancer risk.

Original languageEnglish (US)
JournalCancer
DOIs
StateAccepted/In press - Jan 1 2018

Fingerprint

Weight Loss
Breast Neoplasms
Incidence
Weights and Measures
Confidence Intervals
Body Mass Index
Triple Negative Breast Neoplasms
Body Height
Women's Health
Mammography
Proportional Hazards Models
Self Report
Weight Gain
Observational Studies
Obesity
Odds Ratio
Body Weight

Keywords

  • breast cancer
  • obesity
  • weight loss
  • weight loss intentionality
  • Women’s Health Initiative

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Chlebowski, R. T., Luo, J., Anderson, G. L., Barrington, W., Reding, K., Simon, M. S., ... Stefanick, M. L. (Accepted/In press). Weight loss and breast cancer incidence in postmenopausal women. Cancer. https://doi.org/10.1002/cncr.31687

Weight loss and breast cancer incidence in postmenopausal women. / Chlebowski, Rowan T.; Luo, Juhua; Anderson, Garnet L.; Barrington, Wendy; Reding, Kerryn; Simon, Michael S.; Manson, Jo Ann E.; Rohan, Thomas E.; Wactawski-Wende, Jean; Lane, Dorothy; Strickler, Howard; Mosaver-Rahmani, Yasmin; Freudenheim, Jo L.; Saquib, Nazmus; Stefanick, Marcia L.

In: Cancer, 01.01.2018.

Research output: Contribution to journalArticle

Chlebowski, RT, Luo, J, Anderson, GL, Barrington, W, Reding, K, Simon, MS, Manson, JAE, Rohan, TE, Wactawski-Wende, J, Lane, D, Strickler, H, Mosaver-Rahmani, Y, Freudenheim, JL, Saquib, N & Stefanick, ML 2018, 'Weight loss and breast cancer incidence in postmenopausal women', Cancer. https://doi.org/10.1002/cncr.31687
Chlebowski RT, Luo J, Anderson GL, Barrington W, Reding K, Simon MS et al. Weight loss and breast cancer incidence in postmenopausal women. Cancer. 2018 Jan 1. https://doi.org/10.1002/cncr.31687
Chlebowski, Rowan T. ; Luo, Juhua ; Anderson, Garnet L. ; Barrington, Wendy ; Reding, Kerryn ; Simon, Michael S. ; Manson, Jo Ann E. ; Rohan, Thomas E. ; Wactawski-Wende, Jean ; Lane, Dorothy ; Strickler, Howard ; Mosaver-Rahmani, Yasmin ; Freudenheim, Jo L. ; Saquib, Nazmus ; Stefanick, Marcia L. / Weight loss and breast cancer incidence in postmenopausal women. In: Cancer. 2018.
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abstract = "Background: Although obesity is an established risk factor for postmenopausal breast cancer, the results of weight loss and breast cancer studies are inconsistent. Therefore, we evaluated associations between weight change and breast cancer risk in postmenopausal women in the Women’s Health Initiative Observational Study. Methods: Postmenopausal women (n = 61,335) who had no prior breast cancer and a normal mammogram had body weight and height measured and body mass index (BMI) calculated at baseline and year 3. Weight change at year 3 was categorized as stable (<5{\%}), loss (≥5{\%}), or gain (≥5{\%}) with further assessment of weight loss intentionality by self-report. Multivariable Cox proportional hazard regression models were used to evaluate relationships between weight change and subsequent breast cancer incidence. Results: During a mean follow-up of 11.4 years with 3061 incident breast cancers, women with weight loss (n = 8175) had a significantly lower risk of breast cancer compared with women whose weight remained stable (n = 41,139) (hazard ratio [HR], 0.88; 95{\%} confidence interval [CI], 0.78-0.98; P =.02) with no interaction by BMI. Adjustment for mammography did not alter findings (HR, 0.88; 95{\%} CI, 0.78-0.99) with no significant difference by weight loss intentionality. Weight gain (≥5{\%}) (n = 12,021) was not associated with breast cancer risk (HR, 1.02; 95{\%} CI, 0.93-1.11) but was associated with higher triple-negative breast cancer incidence (HR, 1.54; 95{\%} CI, 1.16-2.05). Conclusions: Postmenopausal women who lose weight have lower breast cancer risk than those with stable weight. These findings suggest that postmenopausal women who lose weight may reduce their breast cancer risk.",
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AU - Anderson, Garnet L.

AU - Barrington, Wendy

AU - Reding, Kerryn

AU - Simon, Michael S.

AU - Manson, Jo Ann E.

AU - Rohan, Thomas E.

AU - Wactawski-Wende, Jean

AU - Lane, Dorothy

AU - Strickler, Howard

AU - Mosaver-Rahmani, Yasmin

AU - Freudenheim, Jo L.

AU - Saquib, Nazmus

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N2 - Background: Although obesity is an established risk factor for postmenopausal breast cancer, the results of weight loss and breast cancer studies are inconsistent. Therefore, we evaluated associations between weight change and breast cancer risk in postmenopausal women in the Women’s Health Initiative Observational Study. Methods: Postmenopausal women (n = 61,335) who had no prior breast cancer and a normal mammogram had body weight and height measured and body mass index (BMI) calculated at baseline and year 3. Weight change at year 3 was categorized as stable (<5%), loss (≥5%), or gain (≥5%) with further assessment of weight loss intentionality by self-report. Multivariable Cox proportional hazard regression models were used to evaluate relationships between weight change and subsequent breast cancer incidence. Results: During a mean follow-up of 11.4 years with 3061 incident breast cancers, women with weight loss (n = 8175) had a significantly lower risk of breast cancer compared with women whose weight remained stable (n = 41,139) (hazard ratio [HR], 0.88; 95% confidence interval [CI], 0.78-0.98; P =.02) with no interaction by BMI. Adjustment for mammography did not alter findings (HR, 0.88; 95% CI, 0.78-0.99) with no significant difference by weight loss intentionality. Weight gain (≥5%) (n = 12,021) was not associated with breast cancer risk (HR, 1.02; 95% CI, 0.93-1.11) but was associated with higher triple-negative breast cancer incidence (HR, 1.54; 95% CI, 1.16-2.05). Conclusions: Postmenopausal women who lose weight have lower breast cancer risk than those with stable weight. These findings suggest that postmenopausal women who lose weight may reduce their breast cancer risk.

AB - Background: Although obesity is an established risk factor for postmenopausal breast cancer, the results of weight loss and breast cancer studies are inconsistent. Therefore, we evaluated associations between weight change and breast cancer risk in postmenopausal women in the Women’s Health Initiative Observational Study. Methods: Postmenopausal women (n = 61,335) who had no prior breast cancer and a normal mammogram had body weight and height measured and body mass index (BMI) calculated at baseline and year 3. Weight change at year 3 was categorized as stable (<5%), loss (≥5%), or gain (≥5%) with further assessment of weight loss intentionality by self-report. Multivariable Cox proportional hazard regression models were used to evaluate relationships between weight change and subsequent breast cancer incidence. Results: During a mean follow-up of 11.4 years with 3061 incident breast cancers, women with weight loss (n = 8175) had a significantly lower risk of breast cancer compared with women whose weight remained stable (n = 41,139) (hazard ratio [HR], 0.88; 95% confidence interval [CI], 0.78-0.98; P =.02) with no interaction by BMI. Adjustment for mammography did not alter findings (HR, 0.88; 95% CI, 0.78-0.99) with no significant difference by weight loss intentionality. Weight gain (≥5%) (n = 12,021) was not associated with breast cancer risk (HR, 1.02; 95% CI, 0.93-1.11) but was associated with higher triple-negative breast cancer incidence (HR, 1.54; 95% CI, 1.16-2.05). Conclusions: Postmenopausal women who lose weight have lower breast cancer risk than those with stable weight. These findings suggest that postmenopausal women who lose weight may reduce their breast cancer risk.

KW - breast cancer

KW - obesity

KW - weight loss

KW - weight loss intentionality

KW - Women’s Health Initiative

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