Wegener granulomatosis with phlyctenular conjunctivitis

Norman Todd Ilowite, S. Kodsi, P. Lanzkowsky, L. Mathias, M. Gandhi, I. R. Shenker, B. Gauthier

Research output: Contribution to journalArticle

Abstract

An 11 year old female presented with a history of sinusitis and of swelling of the right knee for which she was seen at an outlying hospital. She was treated with various antibiotics and then developed a nonpurulent conjunctivitis. About two weeks later she was found to have hematuria and proteinuria. When first seen at the Schneider Children's Hospital, the patient appeared ill and had photophobia. She had severe bilateral conjunctival injection but had no purulent discharge. This was found to be due to phlyctenular conjunctivitis. The rest of the physical examination was normal. ANCA came back positive with a high liter with cytoplasmic staining confirming the clinical impression of Wegener granulomatosis. Wegener granulomatosis used to be uniformly fatal, then was found to respond to aggressive treatment with oral daily cyclophosphamide and high doses of steroids for prolonged periods of time. However, the morbidity of the treatment was a serious problem. This has now been alleviated by the equally effective use of oral methotrexate and steroids. This patient has done well on this regimen.

Original languageEnglish (US)
Pages (from-to)143-145
Number of pages3
JournalChildren's Hospital Quarterly
Volume8
Issue number3
StatePublished - 1996
Externally publishedYes

Fingerprint

Granulomatosis with Polyangiitis
Conjunctivitis
Steroids
Photophobia
Antineutrophil Cytoplasmic Antibodies
Sinusitis
Hematuria
Proteinuria
Methotrexate
Cyclophosphamide
Physical Examination
Knee
Staining and Labeling
Anti-Bacterial Agents
Morbidity
Injections
Therapeutics

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Ilowite, N. T., Kodsi, S., Lanzkowsky, P., Mathias, L., Gandhi, M., Shenker, I. R., & Gauthier, B. (1996). Wegener granulomatosis with phlyctenular conjunctivitis. Children's Hospital Quarterly, 8(3), 143-145.

Wegener granulomatosis with phlyctenular conjunctivitis. / Ilowite, Norman Todd; Kodsi, S.; Lanzkowsky, P.; Mathias, L.; Gandhi, M.; Shenker, I. R.; Gauthier, B.

In: Children's Hospital Quarterly, Vol. 8, No. 3, 1996, p. 143-145.

Research output: Contribution to journalArticle

Ilowite, NT, Kodsi, S, Lanzkowsky, P, Mathias, L, Gandhi, M, Shenker, IR & Gauthier, B 1996, 'Wegener granulomatosis with phlyctenular conjunctivitis', Children's Hospital Quarterly, vol. 8, no. 3, pp. 143-145.
Ilowite NT, Kodsi S, Lanzkowsky P, Mathias L, Gandhi M, Shenker IR et al. Wegener granulomatosis with phlyctenular conjunctivitis. Children's Hospital Quarterly. 1996;8(3):143-145.
Ilowite, Norman Todd ; Kodsi, S. ; Lanzkowsky, P. ; Mathias, L. ; Gandhi, M. ; Shenker, I. R. ; Gauthier, B. / Wegener granulomatosis with phlyctenular conjunctivitis. In: Children's Hospital Quarterly. 1996 ; Vol. 8, No. 3. pp. 143-145.
@article{48dce715eed24d36a985c34f7e77c2fa,
title = "Wegener granulomatosis with phlyctenular conjunctivitis",
abstract = "An 11 year old female presented with a history of sinusitis and of swelling of the right knee for which she was seen at an outlying hospital. She was treated with various antibiotics and then developed a nonpurulent conjunctivitis. About two weeks later she was found to have hematuria and proteinuria. When first seen at the Schneider Children's Hospital, the patient appeared ill and had photophobia. She had severe bilateral conjunctival injection but had no purulent discharge. This was found to be due to phlyctenular conjunctivitis. The rest of the physical examination was normal. ANCA came back positive with a high liter with cytoplasmic staining confirming the clinical impression of Wegener granulomatosis. Wegener granulomatosis used to be uniformly fatal, then was found to respond to aggressive treatment with oral daily cyclophosphamide and high doses of steroids for prolonged periods of time. However, the morbidity of the treatment was a serious problem. This has now been alleviated by the equally effective use of oral methotrexate and steroids. This patient has done well on this regimen.",
author = "Ilowite, {Norman Todd} and S. Kodsi and P. Lanzkowsky and L. Mathias and M. Gandhi and Shenker, {I. R.} and B. Gauthier",
year = "1996",
language = "English (US)",
volume = "8",
pages = "143--145",
journal = "Children's Hospital Quarterly",
issn = "0899-5869",
publisher = "Kluwer/Plenum Publishers",
number = "3",

}

TY - JOUR

T1 - Wegener granulomatosis with phlyctenular conjunctivitis

AU - Ilowite, Norman Todd

AU - Kodsi, S.

AU - Lanzkowsky, P.

AU - Mathias, L.

AU - Gandhi, M.

AU - Shenker, I. R.

AU - Gauthier, B.

PY - 1996

Y1 - 1996

N2 - An 11 year old female presented with a history of sinusitis and of swelling of the right knee for which she was seen at an outlying hospital. She was treated with various antibiotics and then developed a nonpurulent conjunctivitis. About two weeks later she was found to have hematuria and proteinuria. When first seen at the Schneider Children's Hospital, the patient appeared ill and had photophobia. She had severe bilateral conjunctival injection but had no purulent discharge. This was found to be due to phlyctenular conjunctivitis. The rest of the physical examination was normal. ANCA came back positive with a high liter with cytoplasmic staining confirming the clinical impression of Wegener granulomatosis. Wegener granulomatosis used to be uniformly fatal, then was found to respond to aggressive treatment with oral daily cyclophosphamide and high doses of steroids for prolonged periods of time. However, the morbidity of the treatment was a serious problem. This has now been alleviated by the equally effective use of oral methotrexate and steroids. This patient has done well on this regimen.

AB - An 11 year old female presented with a history of sinusitis and of swelling of the right knee for which she was seen at an outlying hospital. She was treated with various antibiotics and then developed a nonpurulent conjunctivitis. About two weeks later she was found to have hematuria and proteinuria. When first seen at the Schneider Children's Hospital, the patient appeared ill and had photophobia. She had severe bilateral conjunctival injection but had no purulent discharge. This was found to be due to phlyctenular conjunctivitis. The rest of the physical examination was normal. ANCA came back positive with a high liter with cytoplasmic staining confirming the clinical impression of Wegener granulomatosis. Wegener granulomatosis used to be uniformly fatal, then was found to respond to aggressive treatment with oral daily cyclophosphamide and high doses of steroids for prolonged periods of time. However, the morbidity of the treatment was a serious problem. This has now been alleviated by the equally effective use of oral methotrexate and steroids. This patient has done well on this regimen.

UR - http://www.scopus.com/inward/record.url?scp=0030318359&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030318359&partnerID=8YFLogxK

M3 - Article

VL - 8

SP - 143

EP - 145

JO - Children's Hospital Quarterly

JF - Children's Hospital Quarterly

SN - 0899-5869

IS - 3

ER -