Wegener granulomatosis

Norman Todd Ilowite, E. Valderrama, H. Trachtman, P. Lanzkowsky, B. Fell, M. Gandhi, I. R. Shenker, B. Gauthier, A. Battista

Research output: Contribution to journalArticle

Abstract

A 15-year-old male presented with a two-week history of low grade temperatures, lethargy and shortness of breath. A chest x-ray showed small bilateral infiltrates and a CBC showed iron deficiency anemia. The patient continued to have worsening of symptoms and an increasing cough. He had no history of rash, weight loss or edema, and was admitted for further evaluation. On admission, there were rales bilaterally but the physical examination was otherwise largely negative. A CBC confirmed the presence of iron deficiency anemia and a urinalysis showed that there was proteinuria and hematuria. The constellation of findings suggested that the patient must have one of two diseases: Goodpasture syndrome or Wegener granulomatosis. A renal biopsy excluded Goodpasture syndrome but did not show changes diagnostic of Wegener granulomstosis. The finding of high titers of cytoplasmic antineutrophil antibodies (C-ANCA) was diagnostic of Wegener granulomatosis a disease that is associated with permanent injury or death in about 87% of patients. The patient was started on methotrexate and corticosteroids.

Original languageEnglish (US)
Pages (from-to)45-47
Number of pages3
JournalChildren's Hospital Quarterly
Volume8
Issue number1
StatePublished - 1996
Externally publishedYes

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Granulomatosis with Polyangiitis
Anti-Glomerular Basement Membrane Disease
Antineutrophil Cytoplasmic Antibodies
Iron-Deficiency Anemias
Lethargy
Urinalysis
Respiratory Sounds
Hematuria
Exanthema
Proteinuria
Cough
Methotrexate
Dyspnea
Physical Examination
Weight Loss
Edema
Adrenal Cortex Hormones
Thorax
X-Rays
Kidney

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Ilowite, N. T., Valderrama, E., Trachtman, H., Lanzkowsky, P., Fell, B., Gandhi, M., ... Battista, A. (1996). Wegener granulomatosis. Children's Hospital Quarterly, 8(1), 45-47.

Wegener granulomatosis. / Ilowite, Norman Todd; Valderrama, E.; Trachtman, H.; Lanzkowsky, P.; Fell, B.; Gandhi, M.; Shenker, I. R.; Gauthier, B.; Battista, A.

In: Children's Hospital Quarterly, Vol. 8, No. 1, 1996, p. 45-47.

Research output: Contribution to journalArticle

Ilowite, NT, Valderrama, E, Trachtman, H, Lanzkowsky, P, Fell, B, Gandhi, M, Shenker, IR, Gauthier, B & Battista, A 1996, 'Wegener granulomatosis', Children's Hospital Quarterly, vol. 8, no. 1, pp. 45-47.
Ilowite NT, Valderrama E, Trachtman H, Lanzkowsky P, Fell B, Gandhi M et al. Wegener granulomatosis. Children's Hospital Quarterly. 1996;8(1):45-47.
Ilowite, Norman Todd ; Valderrama, E. ; Trachtman, H. ; Lanzkowsky, P. ; Fell, B. ; Gandhi, M. ; Shenker, I. R. ; Gauthier, B. ; Battista, A. / Wegener granulomatosis. In: Children's Hospital Quarterly. 1996 ; Vol. 8, No. 1. pp. 45-47.
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AU - Valderrama, E.

AU - Trachtman, H.

AU - Lanzkowsky, P.

AU - Fell, B.

AU - Gandhi, M.

AU - Shenker, I. R.

AU - Gauthier, B.

AU - Battista, A.

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