Weekly 5-fluorouracil combined with PALA: Toxic and therapeutic effects in colorectal cancer

F. M. Muggia; F. J. Camacho; B. H. Kaplan; M. D. Green; E. S. Greenwald; J. C. Wernz; P. F. Engstrom

Weekly 5-fluorouracil combined with PALA: Toxic and therapeutic effects in colorectal cancer

F. M. Muggia, F. J. Camacho, B. H. Kaplan, M. D. Green, E. S. Greenwald, J. C. Wernz, P. F. Engstrom

Research output: Contribution to journal › Article › peer-review

Abstract

A total of 51 patients (eight previously treated) received PALA added to 5-fluorouracil (5FU) given weekly. After 32 patients, the PALA schedule was changed from every other week to weekly, 24 hours preceding 5FU in accordance with preclinical leads (see text). Both schedules were associated with moderately severe toxic effects related primarily to PALA (skin rash) or to the combined effects of both drugs (diarrhea, vomiting, conjunctivitis, and neurotoxicity). Overall nine partial responses were observed, including three in patients previously treated with 5FU. However, future studies with this combination utilizing the current or other previously published schedules are not warranted in colorectal cancer. Since toxicity is a prominent impediment, the possibility of therapeutic synergy may perhaps be explored at drastically reduced doses of PALA, combined with other modulating measures.

Original language	English (US)
Pages (from-to)	253-256
Number of pages	4
Journal	Cancer Treatment Reports
Volume	71
Issue number	3
State	Published - 1987
Externally published	Yes

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

@article{dd73aa6c4dbc4228b2a6c41d6f28f586,

title = "Weekly 5-fluorouracil combined with PALA: Toxic and therapeutic effects in colorectal cancer",

abstract = "A total of 51 patients (eight previously treated) received PALA added to 5-fluorouracil (5FU) given weekly. After 32 patients, the PALA schedule was changed from every other week to weekly, 24 hours preceding 5FU in accordance with preclinical leads (see text). Both schedules were associated with moderately severe toxic effects related primarily to PALA (skin rash) or to the combined effects of both drugs (diarrhea, vomiting, conjunctivitis, and neurotoxicity). Overall nine partial responses were observed, including three in patients previously treated with 5FU. However, future studies with this combination utilizing the current or other previously published schedules are not warranted in colorectal cancer. Since toxicity is a prominent impediment, the possibility of therapeutic synergy may perhaps be explored at drastically reduced doses of PALA, combined with other modulating measures.",

author = "Muggia, {F. M.} and Camacho, {F. J.} and Kaplan, {B. H.} and Green, {M. D.} and Greenwald, {E. S.} and Wernz, {J. C.} and Engstrom, {P. F.}",

year = "1987",

language = "English (US)",

volume = "71",

pages = "253--256",

journal = "Cancer Treatment Reports",

issn = "0361-5960",

publisher = "Oxford University Press",

number = "3",

}

TY - JOUR

T1 - Weekly 5-fluorouracil combined with PALA

T2 - Toxic and therapeutic effects in colorectal cancer

AU - Muggia, F. M.

AU - Camacho, F. J.

AU - Kaplan, B. H.

AU - Green, M. D.

AU - Greenwald, E. S.

AU - Wernz, J. C.

AU - Engstrom, P. F.

PY - 1987

Y1 - 1987

N2 - A total of 51 patients (eight previously treated) received PALA added to 5-fluorouracil (5FU) given weekly. After 32 patients, the PALA schedule was changed from every other week to weekly, 24 hours preceding 5FU in accordance with preclinical leads (see text). Both schedules were associated with moderately severe toxic effects related primarily to PALA (skin rash) or to the combined effects of both drugs (diarrhea, vomiting, conjunctivitis, and neurotoxicity). Overall nine partial responses were observed, including three in patients previously treated with 5FU. However, future studies with this combination utilizing the current or other previously published schedules are not warranted in colorectal cancer. Since toxicity is a prominent impediment, the possibility of therapeutic synergy may perhaps be explored at drastically reduced doses of PALA, combined with other modulating measures.

AB - A total of 51 patients (eight previously treated) received PALA added to 5-fluorouracil (5FU) given weekly. After 32 patients, the PALA schedule was changed from every other week to weekly, 24 hours preceding 5FU in accordance with preclinical leads (see text). Both schedules were associated with moderately severe toxic effects related primarily to PALA (skin rash) or to the combined effects of both drugs (diarrhea, vomiting, conjunctivitis, and neurotoxicity). Overall nine partial responses were observed, including three in patients previously treated with 5FU. However, future studies with this combination utilizing the current or other previously published schedules are not warranted in colorectal cancer. Since toxicity is a prominent impediment, the possibility of therapeutic synergy may perhaps be explored at drastically reduced doses of PALA, combined with other modulating measures.

UR - http://www.scopus.com/inward/record.url?scp=0023150341&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023150341&partnerID=8YFLogxK

M3 - Article

C2 - 3815391

AN - SCOPUS:0023150341

SN - 0361-5960

VL - 71

SP - 253

EP - 256

JO - Cancer Treatment Reports

JF - Cancer Treatment Reports

IS - 3

ER -

Weekly 5-fluorouracil combined with PALA: Toxic and therapeutic effects in colorectal cancer

Abstract

ASJC Scopus subject areas

UN SDGs

Other files and links

Fingerprint

Cite this