Watching single protons bind

Myles H. Akabas

doi:10.1038/nchembio0306-128

Watching single protons bind

Myles H. Akabas

Neuroscience

Research output: Contribution to journal › Short survey › peer-review

Abstract

Using single-molecule biophysical studies in an ion channel, the protonation state of engineered basic amino acids was measured in real time, making it possible to calculate the pK_as of the substituted residues and creating a unique, comprehensive dataset for theorists studying the effects of an electrostatic environment on integral membrane protein function.

Original language	English (US)
Pages (from-to)	128-130
Number of pages	3
Journal	Nature Chemical Biology
Volume	2
Issue number	3
DOIs	https://doi.org/10.1038/nchembio0306-128
State	Published - Mar 2006

ASJC Scopus subject areas

Molecular Biology
Cell Biology

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10.1038/nchembio0306-128

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abstract = "Using single-molecule biophysical studies in an ion channel, the protonation state of engineered basic amino acids was measured in real time, making it possible to calculate the pKas of the substituted residues and creating a unique, comprehensive dataset for theorists studying the effects of an electrostatic environment on integral membrane protein function.",

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Watching single protons bind

Abstract

ASJC Scopus subject areas

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