Wasabi nose: An underreported complication of cyclophosphamide infusions

Ginger L. Janow, Norman T. Ilowite, Dawn M. Wahezi

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Wasabi nose, a term used to describe the nasopharyngeal discomfort experienced during cyclophosphamide infusions, is a rare phenomenon, previously described in case reports of adult oncology patients typically receiving high-dose chemotherapy regimens. The underlying mechanism by which this phenomenon occurs is unknown. We report four cases of children with rheumatic diseases afflicted by profound nasopharyngeal discomfort secondary to low-dose cyclophosphamide infusions. We additionally review the literature regarding potential medical management of these complications and describe our experience using these interventions.

Original languageEnglish (US)
Pages (from-to)1003-1005
Number of pages3
JournalClinical Rheumatology
Issue number7
StatePublished - Jul 2011


  • Cyclophosphamide
  • Drug toxicity
  • Pediatric rheumatology
  • Systemic lupus erythematosus

ASJC Scopus subject areas

  • Rheumatology


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