Wasabi nose: An underreported complication of cyclophosphamide infusions

Ginger L. Janow; Norman T. Ilowite; Dawn M. Wahezi

doi:10.1007/s10067-011-1728-z

Wasabi nose: An underreported complication of cyclophosphamide infusions

Ginger L. Janow, Norman T. Ilowite, Dawn M. Wahezi

Pediatrics

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Wasabi nose, a term used to describe the nasopharyngeal discomfort experienced during cyclophosphamide infusions, is a rare phenomenon, previously described in case reports of adult oncology patients typically receiving high-dose chemotherapy regimens. The underlying mechanism by which this phenomenon occurs is unknown. We report four cases of children with rheumatic diseases afflicted by profound nasopharyngeal discomfort secondary to low-dose cyclophosphamide infusions. We additionally review the literature regarding potential medical management of these complications and describe our experience using these interventions.

Original language	English (US)
Pages (from-to)	1003-1005
Number of pages	3
Journal	Clinical Rheumatology
Volume	30
Issue number	7
DOIs	https://doi.org/10.1007/s10067-011-1728-z
State	Published - Jul 2011

Keywords

Cyclophosphamide
Drug toxicity
Pediatric rheumatology
Systemic lupus erythematosus

ASJC Scopus subject areas

Rheumatology

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10.1007/s10067-011-1728-z

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title = "Wasabi nose: An underreported complication of cyclophosphamide infusions",

abstract = "Wasabi nose, a term used to describe the nasopharyngeal discomfort experienced during cyclophosphamide infusions, is a rare phenomenon, previously described in case reports of adult oncology patients typically receiving high-dose chemotherapy regimens. The underlying mechanism by which this phenomenon occurs is unknown. We report four cases of children with rheumatic diseases afflicted by profound nasopharyngeal discomfort secondary to low-dose cyclophosphamide infusions. We additionally review the literature regarding potential medical management of these complications and describe our experience using these interventions.",

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author = "Janow, {Ginger L.} and Ilowite, {Norman T.} and Wahezi, {Dawn M.}",

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AU - Ilowite, Norman T.

AU - Wahezi, Dawn M.

PY - 2011/7

Y1 - 2011/7

N2 - Wasabi nose, a term used to describe the nasopharyngeal discomfort experienced during cyclophosphamide infusions, is a rare phenomenon, previously described in case reports of adult oncology patients typically receiving high-dose chemotherapy regimens. The underlying mechanism by which this phenomenon occurs is unknown. We report four cases of children with rheumatic diseases afflicted by profound nasopharyngeal discomfort secondary to low-dose cyclophosphamide infusions. We additionally review the literature regarding potential medical management of these complications and describe our experience using these interventions.

AB - Wasabi nose, a term used to describe the nasopharyngeal discomfort experienced during cyclophosphamide infusions, is a rare phenomenon, previously described in case reports of adult oncology patients typically receiving high-dose chemotherapy regimens. The underlying mechanism by which this phenomenon occurs is unknown. We report four cases of children with rheumatic diseases afflicted by profound nasopharyngeal discomfort secondary to low-dose cyclophosphamide infusions. We additionally review the literature regarding potential medical management of these complications and describe our experience using these interventions.

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KW - Drug toxicity

KW - Pediatric rheumatology

KW - Systemic lupus erythematosus

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Wasabi nose: An underreported complication of cyclophosphamide infusions

Abstract

Keywords

ASJC Scopus subject areas

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