[Warfarin effects diminishment by the Clostridium butyricum preparation after cardiac surgery; report of a case]

Takuya Maeda, Hiroyuki Tsukui, Nobuhiro Umehara, Shizuko Iwasa, Tadahisa Sugiura, Minako Hayakawa, Yayoi Kawano, Kenji Yamazaki

Research output: Contribution to journalArticle

Abstract

A 55-year-old gentleman diagnosed with severe aortic insufficiency and annuloaortic ectasia underwent modified Bentall procedure using mechanical valve. Anticoagulation therapy with warfarin was introduced after surgery, but sufficient anticoagulation effect was not achieved with a large amount of dosage. After discontinuing the use of the Clostridium butyricum preparation on postoperative day 29, sufficient anticoagulationt effect was obtained within several days. Clostridium butyricum might change the vitamin K production in the intestinal bacterial flora and attenuated the anticoagulation effect of warfarin.

Original languageEnglish (US)
Pages (from-to)505-507
Number of pages3
JournalKyobu geka. The Japanese journal of thoracic surgery
Volume67
Issue number6
StatePublished - Jun 1 2014
Externally publishedYes

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Clostridium butyricum
Warfarin
Thoracic Surgery
Vitamin K
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

[Warfarin effects diminishment by the Clostridium butyricum preparation after cardiac surgery; report of a case]. / Maeda, Takuya; Tsukui, Hiroyuki; Umehara, Nobuhiro; Iwasa, Shizuko; Sugiura, Tadahisa; Hayakawa, Minako; Kawano, Yayoi; Yamazaki, Kenji.

In: Kyobu geka. The Japanese journal of thoracic surgery, Vol. 67, No. 6, 01.06.2014, p. 505-507.

Research output: Contribution to journalArticle

Maeda, T, Tsukui, H, Umehara, N, Iwasa, S, Sugiura, T, Hayakawa, M, Kawano, Y & Yamazaki, K 2014, '[Warfarin effects diminishment by the Clostridium butyricum preparation after cardiac surgery; report of a case]', Kyobu geka. The Japanese journal of thoracic surgery, vol. 67, no. 6, pp. 505-507.
Maeda, Takuya ; Tsukui, Hiroyuki ; Umehara, Nobuhiro ; Iwasa, Shizuko ; Sugiura, Tadahisa ; Hayakawa, Minako ; Kawano, Yayoi ; Yamazaki, Kenji. / [Warfarin effects diminishment by the Clostridium butyricum preparation after cardiac surgery; report of a case]. In: Kyobu geka. The Japanese journal of thoracic surgery. 2014 ; Vol. 67, No. 6. pp. 505-507.
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