[Warfarin effects diminishment by the Clostridium butyricum preparation after cardiac surgery; report of a case]

Takuya Maeda, Hiroyuki Tsukui, Nobuhiro Umehara, Shizuko Iwasa, Tadahisa Sugiura, Minako Hayakawa, Yayoi Kawano, Kenji Yamazaki

Research output: Contribution to journalArticle


A 55-year-old gentleman diagnosed with severe aortic insufficiency and annuloaortic ectasia underwent modified Bentall procedure using mechanical valve. Anticoagulation therapy with warfarin was introduced after surgery, but sufficient anticoagulation effect was not achieved with a large amount of dosage. After discontinuing the use of the Clostridium butyricum preparation on postoperative day 29, sufficient anticoagulationt effect was obtained within several days. Clostridium butyricum might change the vitamin K production in the intestinal bacterial flora and attenuated the anticoagulation effect of warfarin.

Original languageEnglish (US)
Pages (from-to)505-507
Number of pages3
JournalKyobu geka. The Japanese journal of thoracic surgery
Issue number6
Publication statusPublished - Jun 1 2014
Externally publishedYes


ASJC Scopus subject areas

  • Medicine(all)

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