Walking speed, physical activity, and breast cancer in postmenopausal women

Karen Kwan, Rowan T. Chlebowski, Anne McTiernan, Rebecca J. Rodabough, Michael J. La Monte, Lisa W. Martin, Christina Bell, Dorothy S. Lane, Robert C. Kaplan, Melinda L. Irwin

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Higher self-reported physical activity is associated with lower breast cancer incidence and mortality. Objectively measured timed walking speed, predictive of longevity in older adults, has been associated with ambulatory physical activity in small studies but definitive assessment of the association is lacking. Participants were a subset of 14 719 postmenopausal women in the Women's Health Initiative study who, at entry, had 10 m, timed walking speed determined. After 12.4 years [mean (SD) (3.5)] follow-up, 762 invasive breast cancers were diagnosed in this group. In addition, 8162 of these women self-reported physical activity. Simple linear regression was used to examine the relationship between timed walking speed and self-reported physical activity. A Cox proportional hazard model was used to estimate age-adjusted hazard ratios and 95% confidence intervals for the association between timed walking speed and invasive breast cancer incidence. Although a linear regression model for self-reported physical activity [log metabolic equivalent task (MET) h/week] versus 10 m, timed walking speed had a statistically significant slope (coefficient=0.03, P<0.0001, correlation=0.20), the magnitude of the relationship was not clinically useful. Timed walking speed quintile was not associated with breast cancer incidence in age-adjusted or multivariant analyses (P for trend=0.60). Timed walking speed was not associated with self-reported physical activity in a clinically useful manner or with breast cancer incidence. Our findings do not support use of timed walking speed as an objective surrogate for self-reported physical activity.

Original languageEnglish (US)
Pages (from-to)49-52
Number of pages4
JournalEuropean Journal of Cancer Prevention
Volume23
Issue number1
DOIs
StatePublished - Jan 2014

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Exercise
Breast Neoplasms
Linear Models
Incidence
Metabolic Equivalent
Walking Speed
Women's Health
Proportional Hazards Models
Confidence Intervals
Mortality

Keywords

  • 10-m walk test
  • Breast cancer
  • Physical activity
  • Walking speed

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Epidemiology
  • Public Health, Environmental and Occupational Health

Cite this

Kwan, K., Chlebowski, R. T., McTiernan, A., Rodabough, R. J., La Monte, M. J., Martin, L. W., ... Irwin, M. L. (2014). Walking speed, physical activity, and breast cancer in postmenopausal women. European Journal of Cancer Prevention, 23(1), 49-52. https://doi.org/10.1097/CEJ.0b013e328361627e

Walking speed, physical activity, and breast cancer in postmenopausal women. / Kwan, Karen; Chlebowski, Rowan T.; McTiernan, Anne; Rodabough, Rebecca J.; La Monte, Michael J.; Martin, Lisa W.; Bell, Christina; Lane, Dorothy S.; Kaplan, Robert C.; Irwin, Melinda L.

In: European Journal of Cancer Prevention, Vol. 23, No. 1, 01.2014, p. 49-52.

Research output: Contribution to journalArticle

Kwan, K, Chlebowski, RT, McTiernan, A, Rodabough, RJ, La Monte, MJ, Martin, LW, Bell, C, Lane, DS, Kaplan, RC & Irwin, ML 2014, 'Walking speed, physical activity, and breast cancer in postmenopausal women', European Journal of Cancer Prevention, vol. 23, no. 1, pp. 49-52. https://doi.org/10.1097/CEJ.0b013e328361627e
Kwan K, Chlebowski RT, McTiernan A, Rodabough RJ, La Monte MJ, Martin LW et al. Walking speed, physical activity, and breast cancer in postmenopausal women. European Journal of Cancer Prevention. 2014 Jan;23(1):49-52. https://doi.org/10.1097/CEJ.0b013e328361627e
Kwan, Karen ; Chlebowski, Rowan T. ; McTiernan, Anne ; Rodabough, Rebecca J. ; La Monte, Michael J. ; Martin, Lisa W. ; Bell, Christina ; Lane, Dorothy S. ; Kaplan, Robert C. ; Irwin, Melinda L. / Walking speed, physical activity, and breast cancer in postmenopausal women. In: European Journal of Cancer Prevention. 2014 ; Vol. 23, No. 1. pp. 49-52.
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