Walking speed and risk of incident ischemic stroke among postmenopausal women

Aileen P. McGinn, Robert C. Kaplan, Joe Verghese, Daniel M. Rosenbaum, Bruce M. Psaty, Alison E. Baird, John K. Lynch, Philip A. Wolf, Charles Kooperberg, Joseph C. Larson, Sylvia Wassertheil-Smoller

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

BACKGROUND AND PURPOSE - Walking speed is a simple, reliable, and valid measure of functional status that has been shown to be strongly correlated with age-related outcomes and may be an indicator of subclinical cerebrovascular disease. However, few studies have investigated the association of walking speed with risk of incident ischemic stroke. METHODS - The present analyses included 13 048 postmenopausal women (mean age 65 years) from the Women's Health Initiative free of stroke at baseline, 264 of whom had incident ischemic strokes on follow-up. Cox proportional hazards regression was used to obtain hazard ratios (HRs) and 95% confidence intervals (CIs) to assess the relationship between performance on a timed walk and risk of incident ischemic stroke. Multivariate adjustment included age, race/ethnicity, body mass index, waist-hip ratio, depression, arthritis, hypertension, smoking, systolic blood pressure, treated diabetes, hormone use, NSAID use, aspirin use, self-reported general health, and history of coronary heart disease. RESULTS - Slower walking speed was a significant predictor of incident ischemic stroke. After multivariate adjustment, the hazard for incident ischemic stroke was increased for the slowest walking speed tertile compared to the fastest walking speed tertile (HR=1.69, 95% CI: 1.21, 2.36). Additional adjustment for other physical function variables (grip strength and chair stands) did not change the association significantly. CONCLUSIONS - Slow walking speed was found to be a strong predictor of increased risk of incident ischemic stroke among postmenopausal women independent of other established risk factors for stroke.

Original languageEnglish (US)
Pages (from-to)1233-1239
Number of pages7
JournalStroke
Volume39
Issue number4
DOIs
StatePublished - Apr 2008

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Stroke
Social Adjustment
Confidence Intervals
Blood Pressure
Cerebrovascular Disorders
Waist-Hip Ratio
Walking Speed
Hand Strength
Women's Health
Non-Steroidal Anti-Inflammatory Agents
Aspirin
Arthritis
Coronary Disease
Body Mass Index
Smoking
Hormones
Depression
Hypertension
Health

Keywords

  • Physical function
  • Stroke
  • Walking speed
  • Women

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Neuroscience(all)

Cite this

Walking speed and risk of incident ischemic stroke among postmenopausal women. / McGinn, Aileen P.; Kaplan, Robert C.; Verghese, Joe; Rosenbaum, Daniel M.; Psaty, Bruce M.; Baird, Alison E.; Lynch, John K.; Wolf, Philip A.; Kooperberg, Charles; Larson, Joseph C.; Wassertheil-Smoller, Sylvia.

In: Stroke, Vol. 39, No. 4, 04.2008, p. 1233-1239.

Research output: Contribution to journalArticle

McGinn, AP, Kaplan, RC, Verghese, J, Rosenbaum, DM, Psaty, BM, Baird, AE, Lynch, JK, Wolf, PA, Kooperberg, C, Larson, JC & Wassertheil-Smoller, S 2008, 'Walking speed and risk of incident ischemic stroke among postmenopausal women', Stroke, vol. 39, no. 4, pp. 1233-1239. https://doi.org/10.1161/STROKEAHA.107.500850
McGinn, Aileen P. ; Kaplan, Robert C. ; Verghese, Joe ; Rosenbaum, Daniel M. ; Psaty, Bruce M. ; Baird, Alison E. ; Lynch, John K. ; Wolf, Philip A. ; Kooperberg, Charles ; Larson, Joseph C. ; Wassertheil-Smoller, Sylvia. / Walking speed and risk of incident ischemic stroke among postmenopausal women. In: Stroke. 2008 ; Vol. 39, No. 4. pp. 1233-1239.
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AU - Baird, Alison E.

AU - Lynch, John K.

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