TY - JOUR
T1 - Waking State
T2 - Rapid Variations Modulate Neural and Behavioral Responses
AU - McGinley, Matthew J.
AU - Vinck, Martin
AU - Reimer, Jacob
AU - Batista-Brito, Renata
AU - Zagha, Edward
AU - Cadwell, Cathryn R.
AU - Tolias, Andreas S.
AU - Cardin, Jessica A.
AU - McCormick, David A.
N1 - Publisher Copyright:
© 2015 Elsevier Inc.
PY - 2015/9/23
Y1 - 2015/9/23
N2 - The state of the brain and body constantly varies on rapid and slow timescales. These variations contribute to the apparent noisiness of sensory responses at both the neural and the behavioral level. Recent investigations of rapid state changes in awake, behaving animals have provided insight into the mechanisms by which optimal sensory encoding and behavioral performance are achieved. Fluctuations in state, as indexed by pupillometry, impact both the "signal" (sensory evoked response) and the "noise" (spontaneous activity) of cortical responses. By taking these fluctuations into account, neural response (co)variability is significantly reduced, revealing the brain to be more reliable and predictable than previously thought. The waking brain appears to be noisy, giving rise to variable responses. McGinley et al. review literature that reveals the careful monitoring of waking can control for these variations and reveal a brain that is both reliable and predictable.
AB - The state of the brain and body constantly varies on rapid and slow timescales. These variations contribute to the apparent noisiness of sensory responses at both the neural and the behavioral level. Recent investigations of rapid state changes in awake, behaving animals have provided insight into the mechanisms by which optimal sensory encoding and behavioral performance are achieved. Fluctuations in state, as indexed by pupillometry, impact both the "signal" (sensory evoked response) and the "noise" (spontaneous activity) of cortical responses. By taking these fluctuations into account, neural response (co)variability is significantly reduced, revealing the brain to be more reliable and predictable than previously thought. The waking brain appears to be noisy, giving rise to variable responses. McGinley et al. review literature that reveals the careful monitoring of waking can control for these variations and reveal a brain that is both reliable and predictable.
UR - http://www.scopus.com/inward/record.url?scp=84942156223&partnerID=8YFLogxK
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U2 - 10.1016/j.neuron.2015.09.012
DO - 10.1016/j.neuron.2015.09.012
M3 - Review article
C2 - 26402600
AN - SCOPUS:84942156223
SN - 0896-6273
VL - 87
SP - 1143
EP - 1161
JO - Neuron
JF - Neuron
IS - 6
ER -