Vulvar melanoma with isolated metastasis to the extraocular muscles: Case report and brief literature review

Aneesh K. Pirlamarla, Justin Tang, Bijal D. Amin, Rafi Kabarriti

Research output: Contribution to journalReview article


Background/Aim: Orbital metastasis of systemic cancer is exceedingly rare. This is a case report of a patient treated for locally recurrent vulvar melanoma who later presented with unilateral proptosis and was found to have an isolated biopsy-proven extraocular muscle metastasis. Patients and Methods: A 94-year-old female with locally recurrent vulvar melanoma presented with eye discomfort and blurry vision. Patient underwent histopathological, genetic, and imaging studies. Results: All prior work-up, including brain MRI and PET/CT, was negative for disease elsewhere from local recurrence. Orbital MRI demonstrated a mass involving the extraocular muscle, and immunohistochemistry staining of biopsy was consistent with metastasis. The patient underwent radiation therapy and tolerated treatment well. Conclusion: This is the first reported case of vulvar melanoma with extraocular muscle metastasis. The absence of findings on imaging as part of the staging work-up underscores the importance of considering extraocular muscle (EOM) metastasis as a differential for patients with vulvar melanoma who present with proptosis.

Original languageEnglish (US)
Pages (from-to)3763-3766
Number of pages4
JournalAnticancer Research
Issue number6
Publication statusPublished - Jun 1 2018



  • Gynecologic cancer
  • Orbital metastasis
  • Vulvar melanoma

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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