Volumetric erythrocyte macrocytosis induced by hydroxyurea

Edward R. Burns, L. J. Reed, B. Wenz

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

An atypical form of macrocytosis termed volumetric macrocytosis is described. In contrast to the macrocyte associated with megaloblastic anemia and the pseudomacrocyte caused by viscoelastic defects, the volumetric macrocyte is characterized by an increased mean corpuscular volume and a normal cell diameter. The volumetric macrocyte proves to be thicker than the normocytic red blood cell. This large erythrocyte is overhydrated and contains an increased quantity of hemoglobin. The cell has many characteristics in common with the red blood cells of neonates. Volumetric macrocytosis accompanies sustained hydroxyurea therapy and may represent a drug-induced dyserythropoiesis.

Original languageEnglish (US)
Pages (from-to)337-341
Number of pages5
JournalAmerican Journal of Clinical Pathology
Volume85
Issue number3
StatePublished - 1986

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Hydroxyurea
Erythrocytes
Megaloblastic Anemia
Erythrocyte Indices
Hemoglobins
Pharmaceutical Preparations
Therapeutics

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Volumetric erythrocyte macrocytosis induced by hydroxyurea. / Burns, Edward R.; Reed, L. J.; Wenz, B.

In: American Journal of Clinical Pathology, Vol. 85, No. 3, 1986, p. 337-341.

Research output: Contribution to journalArticle

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