Volume resuscitation from hemorrhagic shock with albumin and hexaPEGylated human serum albumin

Pedro Cabrales, Amy G. Tsai, K. Ananda, Seetharama A. Acharya, Marcos Intaglietta

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

The effect of restoring intravascular volume with polyethylene glycol (PEG) conjugated to human serum albumin (PEG-Alb) on systemic parameters and microvascular hemodynamics after hemorrhagic shock resuscitation was studied in the hamster window chamber model. Moderate hemorrhagic shock was induced by controlled arterial bleeding of 50% of blood volume, and hypovolemia was maintained for 1 h. Fluid resuscitation was accomplished by infusion of 25% of blood volume and recovery was followed over 90 min. The PEG-Alb (six chains of maleimide phenyl PEG conjugated human serum albumin at 4%) resuscitation group was compared human serum albumin (HSA) at 5% (HSA5) and 10% (HSA10) protein concentrations. Systemic parameters, microvascular perfusion and capillary perfusion (functional capillary density, FCD) were measured by noninvasive methods. Hyperoncotic solutions provided rapid restoration of blood pressure, blood gas parameters and microvascular perfusion. Systemic and microvascular recovery was best and most rapid with PEG-Alb and followed by HSA10 and HSA5. Only recovery with PEG-Alb was sustained beyond 90 min. Hemodynamic functional benefits of PEG-Alb and the potential disadvantages associated with HSA, suggest PEG-Alb as better resuscitation solution.

Original languageEnglish (US)
Pages (from-to)139-146
Number of pages8
JournalResuscitation
Volume79
Issue number1
DOIs
StatePublished - Oct 2008

Fingerprint

Hemorrhagic Shock
Resuscitation
Serum Albumin
Albumins
Perfusion
Blood Volume
Hemodynamics
Hypovolemia
Cricetinae
Gases
Hemorrhage
Blood Pressure

Keywords

  • Functional capillary density
  • HexaPEGylation
  • Microcirculation
  • Plasma expander

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Nursing(all)

Cite this

Volume resuscitation from hemorrhagic shock with albumin and hexaPEGylated human serum albumin. / Cabrales, Pedro; Tsai, Amy G.; Ananda, K.; Acharya, Seetharama A.; Intaglietta, Marcos.

In: Resuscitation, Vol. 79, No. 1, 10.2008, p. 139-146.

Research output: Contribution to journalArticle

Cabrales, Pedro ; Tsai, Amy G. ; Ananda, K. ; Acharya, Seetharama A. ; Intaglietta, Marcos. / Volume resuscitation from hemorrhagic shock with albumin and hexaPEGylated human serum albumin. In: Resuscitation. 2008 ; Vol. 79, No. 1. pp. 139-146.
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