Voltage-Gated P/Q-Type Calcium Channel Antibodies Associated With Cerebellar Degeneration

Mary C. Spiciarich, Solomon L. Moshé

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Background Paraneoplastic cerebellar degeneration is a rare neurological condition characterized by diffuse cerebellar dysfunction and magnetic resonance imaging evidence of progressive cerebellar atrophy. It has been associated with several autoantibodies and malignancies in adults. To date, only six cases have been described in male children. Patient Description We describe an eight-year-old girl with a prodrome of abdominal pain and vomiting followed by acute onset diplopia, dysarthria, dysmetria, and ataxia. She was found to have cerebellar degeneration in association with P/Q-type calcium channel antibodies. Conclusion This is the first child with documented paraneoplastic cerebellar degeneration in association with P/Q-type calcium channel antibodies.

Original languageEnglish (US)
Pages (from-to)43-46
Number of pages4
JournalPediatric Neurology
Volume62
DOIs
StatePublished - Jan 1 2016

Keywords

  • cerebellar degeneration
  • child
  • female
  • paraneoplastic
  • voltage-gated calcium channel antibodies

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Neurology
  • Developmental Neuroscience
  • Clinical Neurology

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